DegronMD

Uniprot ID: Q9BSJ5

Source protein: Uncharacterized protein C17orf80

Source gene: C17orf80

Class: DEG_APCC_DBOX_1

Location: 254:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9241

ASA_SCORE: 81.6111

COIL: 0.8848

CONS_SCORE: 0.4867

DSS_SCORE: 0.5935

HELIX: 0.0643

FCONS_SCORE: 0.9941

RIG_SCORE: 0.6334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250K	TCGA-E5-A4TZ	BLCA	TCGA	GRDHLSGVP	DEG_APCC_DBOX_1	0.2222
p.R250K	DO44055	BLCA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	0.2222
p.P271L	TCGA-QR-A706	PCPG	TCGA	GRDHLSGVP	DEG_APCC_DBOX_1	0.0833
p.P271L	DO220906	MELA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	0.0833
p.P262S	DO228017	SKCA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	0.5641
p.L246V	SIDM01588	Endometrial Carcinoma	GDSC	GRDHLSGVP	DEG_APCC_DBOX_1	0.1111
p.L246V	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	0.1111
p.D251V	ACH-001369	Ovarian Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	0.25
p.E272G	ACH-002399	Breast Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ5	Uncharacterized protein C17orf80	DEG_APCC_DBOX_1	254:262	GRDHLSGVP	APC,CDC20,FZR1	0.9241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons