DegronMD - Q9BSJ5(C17orf80)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D196V	TCGA-85-8351	LUSC	TCGA	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.D196V	DO45447	LUSC	ICGC	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.T200A	TCGA-BH-A0BZ	BRCA	TCGA	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.T200A	DO1396	BRCA	ICGC	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.R250K	TCGA-E5-A4TZ	BLCA	TCGA	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2222
p.R250K	DO44055	BLCA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2222
p.N195K	TCGA-EO-A22R	UCEC	TCGA	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.N195K	DO42713	UCEC	ICGC	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.P271L	TCGA-QR-A706	PCPG	TCGA	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0833
p.P271L	DO220906	MELA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0833
p.P262S	DO228017	SKCA	ICGC	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation altering degron motif	0.5641
p.P211H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.P211H	ACH-000937	Leukemia	CCLE	VQTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.L246V	SIDM01588	Endometrial Carcinoma	GDSC	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1111
p.L246V	ACH-000993	Endometrial/Uterine Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1111
p.D251V	ACH-001369	Ovarian Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.25
p.E272G	ACH-002399	Breast Cancer	CCLE	GRDHLSGVP	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556

Kaplan plot for C17orf80 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C17orf80

UniProt ID: Q9BSJ5

Entrez ID: 55028

Protein name: Uncharacterized protein C17orf80 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C17orf80 in