DegronMD

Uniprot ID: Q9BSJ5

Source protein: Uncharacterized protein C17orf80

Source gene: C17orf80

Class: DEG_SPOP_SBC_1

Location: 197:201

E3 ligase: SPOP

DEGRON score: 0.8317

ASA_SCORE: 82.38

COIL: 0.8484

CONS_SCORE: 0.2963

DSS_SCORE: 0.4827

HELIX: 0.0516

FCONS_SCORE: 0.5946

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D196V	TCGA-85-8351	LUSC	TCGA	VQTTS	DEG_SPOP_SBC_1	0.3056
p.D196V	DO45447	LUSC	ICGC	VQTTS	DEG_SPOP_SBC_1	0.3056
p.T200A	TCGA-BH-A0BZ	BRCA	TCGA	VQTTS	DEG_SPOP_SBC_1	0.7139
p.T200A	DO1396	BRCA	ICGC	VQTTS	DEG_SPOP_SBC_1	0.7139
p.N195K	TCGA-EO-A22R	UCEC	TCGA	VQTTS	DEG_SPOP_SBC_1	0.2778
p.N195K	DO42713	UCEC	ICGC	VQTTS	DEG_SPOP_SBC_1	0.2778
p.P211H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VQTTS	DEG_SPOP_SBC_1	0.0556
p.P211H	ACH-000937	Leukemia	CCLE	VQTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSJ5	Uncharacterized protein C17orf80	DEG_SPOP_SBC_1	197:201	VQTTS	SPOP	0.8317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons