DegronMD

Uniprot ID: Q9UBZ9

Source protein: DNA repair protein REV1

Source gene: REV1

Class: DEG_APCC_DBOX_1

Location: 385:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7941

ASA_SCORE: 90.5222

COIL: 0.2886

CONS_SCORE: 0.2406

DSS_SCORE: 0.4591

HELIX: 0.6959

FCONS_SCORE: 1.1342

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S397Y	TCGA-19-5956	GBM	TCGA	GREKLKKMK	DEG_APCC_DBOX_1	0.2222
p.S397Y	DO13863	GBM	ICGC	GREKLKKMK	DEG_APCC_DBOX_1	0.2222
p.R396T	TCGA-B0-4811	KIRC	TCGA	GREKLKKMK	DEG_APCC_DBOX_1	0.25
p.R396T	DO17552	KIRC	ICGC	GREKLKKMK	DEG_APCC_DBOX_1	0.25
p.S397F	TCGA-B5-A3FA	UCEC	TCGA	GREKLKKMK	DEG_APCC_DBOX_1	0.2222
p.S397F	DO52402	UCEC	ICGC	GREKLKKMK	DEG_APCC_DBOX_1	0.2222
p.T394K	DO229038	LICA	ICGC	GREKLKKMK	DEG_APCC_DBOX_1	0.3056
p.M392I	DO220891	MELA	ICGC	GREKLKKMK	DEG_APCC_DBOX_1	0.6507
p.N380S	SIDM00845	Burkitt's Lymphoma	GDSC	GREKLKKMK	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBZ9	DNA repair protein REV1	DEG_APCC_DBOX_1	385:393	GREKLKKMK	APC,CDC20,FZR1	0.7941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons