DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_APCC_DBOX_1

Location: 552:560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6751

ASA_SCORE: 72.7778

COIL: 0.2326

CONS_SCORE: 0.3053

DSS_SCORE: 0.428

HELIX: 0.7486

FCONS_SCORE: 0.7946

RIG_SCORE: 0.8178

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D557N	TCGA-CR-7395	HNSC	TCGA	GRFKLDILK	DEG_APCC_DBOX_1	0.5821
p.D557N	DO14274	HNSC	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.5821
p.K564N	SIDM01198	Burkitt's Lymphoma	GDSC	GRFKLDILK	DEG_APCC_DBOX_1	0.3333
p.K564N	ACH-000567	Lymphoma	CCLE	GRFKLDILK	DEG_APCC_DBOX_1	0.3333
p.K564N	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	GRFKLDILK	DEG_APCC_DBOX_1	0.3333
p.K564R	SIDM00975	Melanoma	GDSC	GRFKLDILK	DEG_APCC_DBOX_1	0.3333
p.N561H	DO222884	COCA	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.3056
p.K562R	DO220876	MELA	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.2778
p.T549S	TCGA-D7-A6EY	STAD	TCGA	GRFKLDILK	DEG_APCC_DBOX_1	0.25
p.T549S	DO50118	STAD	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.25
p.N547H	TCGA-EY-A1GI	UCEC	TCGA	GRFKLDILK	DEG_APCC_DBOX_1	0.1944
p.N547H	DO41211	UCEC	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.1944
p.N547S	ACH-001063	Ovarian Cancer	CCLE	GRFKLDILK	DEG_APCC_DBOX_1	0.1944
p.E546K	TCGA-A5-A0G2	UCEC	TCGA	GRFKLDILK	DEG_APCC_DBOX_1	0.1667
p.E546K	DO41235	UCEC	ICGC	GRFKLDILK	DEG_APCC_DBOX_1	0.1667
p.S542G	SIDM01039	Other Solid Cancers	GDSC	GRFKLDILK	DEG_APCC_DBOX_1	0.0556
p.S542G	JAR	placenta	COSMIC	GRFKLDILK	DEG_APCC_DBOX_1	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_APCC_DBOX_1	552:560	GRFKLDILK	APC,CDC20,FZR1	0.6751	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons