DegronMD

Uniprot ID: Q9H3P2

Source protein: Negative elongation factor A

Source gene: NELFA

Class: DEG_APCC_DBOX_1

Location: 201:209

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9895

ASA_SCORE: 99.2111

COIL: 0.8483

CONS_SCORE: 0.6282

DSS_SCORE: 0.5866

HELIX: 0.0767

FCONS_SCORE: 1.0525

RIG_SCORE: 0.7145

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R202L	TCGA-95-7562	LUAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.8428
p.R217W	TCGA-A5-A0VQ	UCEC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217W	TCGA-PK-A5HB	ACC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217W	DO42113	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217Q	TCGA-CA-6715	COAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217Q	TCGA-HU-A4GQ	STAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217Q	DO9690	COAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R217Q	DO47767	STAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.R202W	TCGA-D1-A103	UCEC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.8634
p.Q191H	TCGA-MV-A51V	BLCA	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	0.0556
p.T193M	DO49929	CESC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.T193M	DO42097	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.1111
p.A199T	DO10582	COAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.2778
p.S200A	DO229010	COCA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.3056
p.P207T	DO228976	LICA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.7031
p.S205R	DO229032	LICA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.7427
p.I203N	DO233295	NACA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.728
p.A211S	DO40996	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	0.2778
p.R213Q	SIDM00449	B-Lymphoblastic Leukemia	GDSC	GRGLLRKMD	DEG_APCC_DBOX_1	0.2222
p.R213Q	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	0.2222
p.F208L	SIDM00537	Colorectal Carcinoma	GDSC	GRGLLRKMD	DEG_APCC_DBOX_1	0.6981
p.F208L	GP5d	large_intestine	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	0.6981
p.R202Q	ACH-000922	Leukemia	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	0.7329
p.R202Q	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	0.7329
p.F197L	ACH-000982	Colon/Colorectal Cancer	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	0.2222
p.F197L	ACH-001345	Colon/Colorectal Cancer	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	0.2222
p.F197L	GP5d	large_intestine	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRGLLRKMD

Degron related mutations and impact score

Drug responses associated with NELFA mutations

All proteins holding degron of GRGLLRKMD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3P2	Negative elongation factor A	DEG_APCC_DBOX_1	201:209	GRGLLRKMD	APC,CDC20,FZR1	0.9895	More...