DegronMD - Q9H3P2(NELFA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R202L	TCGA-95-7562	LUAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8428
p.R217W	TCGA-A5-A0VQ	UCEC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217W	TCGA-PK-A5HB	ACC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217W	DO42113	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217Q	TCGA-CA-6715	COAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217Q	TCGA-HU-A4GQ	STAD	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217Q	DO9690	COAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.R217Q	DO47767	STAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.A400V	TCGA-CF-A3MH	BLCA	TCGA	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.0556
p.A400V	TCGA-XK-AAIW	PRAD	TCGA	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.0556
p.A400V	DO791	BLCA	ICGC	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.0556
p.A400V	DO51407	PRAD	ICGC	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.0556
p.R202W	TCGA-D1-A103	UCEC	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.8634
p.P422L	TCGA-D3-A51G	SKCM	TCGA	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.2222
p.P422S	TCGA-D3-A51G	SKCM	TCGA	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.2222
p.P422S	DO47700	SKCM	ICGC	PPVAMVAPQ	DEG_SIAH_1	410:418	Mutation rewiring degron network	0.2222
p.Q191H	TCGA-MV-A51V	BLCA	TCGA	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.0556
p.T193M	DO49929	CESC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.T193M	DO42097	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.1111
p.A199T	DO10582	COAD	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2778
p.S200A	DO229010	COCA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.3056
p.P207T	DO228976	LICA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7031
p.S205R	DO229032	LICA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7427
p.I203N	DO233295	NACA	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.728
p.A211S	DO40996	UCEC	ICGC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2778
p.R213Q	SIDM00449	B-Lymphoblastic Leukemia	GDSC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.R213Q	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.F208L	SIDM00537	Colorectal Carcinoma	GDSC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6981
p.F208L	GP5d	large intestine	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.6981
p.R202Q	ACH-000922	Leukemia	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7329
p.R202Q	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation altering degron motif	0.7329
p.F197L	ACH-000982	Colon/Colorectal Cancer	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.F197L	ACH-001345	Colon/Colorectal Cancer	CCLE	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222
p.F197L	GP5d	large intestine	COSMIC	GRGLLRKMD	DEG_APCC_DBOX_1	201:209	Mutation rewiring degron network	0.2222

Kaplan plot for NELFA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NELFA

UniProt ID: Q9H3P2

Entrez ID: 7469

Protein name: Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NELFA in