DegronMD

Uniprot ID: Q9H3P2

Source protein: Negative elongation factor A

Source gene: NELFA

Class: DEG_SIAH_1

Location: 410:418

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.911

ASA_SCORE: 94.8

COIL: 0.9327

CONS_SCORE: 0.504

DSS_SCORE: 0.6721

HELIX: 0.0251

FCONS_SCORE: 0.9311

RIG_SCORE: 0.7092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A400V	TCGA-CF-A3MH	BLCA	TCGA	PPVAMVAPQ	DEG_SIAH_1	0.0556
p.A400V	TCGA-XK-AAIW	PRAD	TCGA	PPVAMVAPQ	DEG_SIAH_1	0.0556
p.A400V	DO791	BLCA	ICGC	PPVAMVAPQ	DEG_SIAH_1	0.0556
p.A400V	DO51407	PRAD	ICGC	PPVAMVAPQ	DEG_SIAH_1	0.0556
p.P422L	TCGA-D3-A51G	SKCM	TCGA	PPVAMVAPQ	DEG_SIAH_1	0.2222
p.P422S	TCGA-D3-A51G	SKCM	TCGA	PPVAMVAPQ	DEG_SIAH_1	0.2222
p.P422S	DO47700	SKCM	ICGC	PPVAMVAPQ	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3P2	Negative elongation factor A	DEG_SIAH_1	410:418	PPVAMVAPQ	SIAH1,SIAH2,SIAH3	0.911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons