DegronMD

Uniprot ID: Q96T60

Source protein: Bifunctional polynucleotide phosphatase/kinase

Source gene: PNKP

Class: DEG_APCC_DBOX_1

Location: 34:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8732

ASA_SCORE: 57.3111

COIL: 0.7038

CONS_SCORE: 0.3012

DSS_SCORE: 0.4431

HELIX: 0.0368

FCONS_SCORE: 0.9192

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C46F	TCGA-A7-A0DA	BRCA	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	0.2222
p.C46F	DO5870	BRCA	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	0.2222
p.G28W	TCGA-BF-A1PZ	SKCM	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	0.1667
p.G28W	DO50279	SKCM	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	0.1667
p.E52K	TCGA-DR-A0ZM	CESC	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	0.0556
p.E52K	DO6254	CESC	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	0.0556
p.S26L	TCGA-FW-A3R5	SKCM	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	0.1111
p.S26L	DO37406	SKCM	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	0.1111
p.E52Q	DO1127	BRCA	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	0.0556
p.P37S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	0.5641
p.P37S	ACH-000924	Lung Cancer	CCLE	GRGPLTQVT	DEG_APCC_DBOX_1	0.5641
p.P37S	NCI-H2172	lung	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	0.5641
p.T42R	SIDM00290	Gastric Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	0.6765
p.T42R	ACH-000847	Gastric Cancer	CCLE	GRGPLTQVT	DEG_APCC_DBOX_1	0.6765
p.T42R	HGC-27	stomach	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	0.6765
p.V51L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	0.0833
p.V51L	NCI-H650	lung	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T60	Bifunctional polynucleotide phosphatase/kinase	DEG_APCC_DBOX_1	34:42	GRGPLTQVT	APC,CDC20,FZR1	0.8732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons