DegronMD - Q96T60(PNKP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L124V	TCGA-67-3771	LUAD	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.2778
p.L124V	DO25797	LUAD	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.2778
p.C46F	TCGA-A7-A0DA	BRCA	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.2222
p.C46F	DO5870	BRCA	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.2222
p.S126F	TCGA-AX-A2HC	UCEC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6667
p.S126F	DO41572	UCEC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6667
p.G28W	TCGA-BF-A1PZ	SKCM	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.G28W	DO50279	SKCM	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.P119L	TCGA-BS-A0UF	UCEC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.7582
p.P119L	DO41488	UCEC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.7582
p.P119L	ACH-001184	Sarcoma	CCLE	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.7582
p.W106C	TCGA-CR-7388	HNSC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.0556
p.W106C	TCGA-EE-A2GN	SKCM	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.0556
p.W106C	DO14284	HNSC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.0556
p.W106C	DO37896	SKCM	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.0556
p.D117Y	TCGA-DA-A1I1	SKCM	TCGA	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.6214
p.D117Y	DO37966	SKCM	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.6214
p.E52K	TCGA-DR-A0ZM	CESC	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0556
p.E52K	DO6254	CESC	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0556
p.S26L	TCGA-FW-A3R5	SKCM	TCGA	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1111
p.S26L	DO37406	SKCM	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1111
p.E52Q	DO1127	BRCA	ICGC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0556
p.P112R	DO52481	COCA	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.2222
p.P119S	DO220891	MELA	ICGC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.6752
p.P119S	ACH-001184	Sarcoma	CCLE	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.6752
p.P37S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5641
p.P37S	ACH-000924	Lung Cancer	CCLE	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5641
p.P37S	NCI-H2172	lung	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5641
p.S126T	SIDM01045	Endometrial Carcinoma	GDSC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6667
p.S126T	ACH-000978	Endometrial/Uterine Cancer	CCLE	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6667
p.S126T	EN	endometrium	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6667
p.T42R	SIDM00290	Gastric Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6765
p.T42R	ACH-000847	Gastric Cancer	CCLE	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6765
p.T42R	HGC-27	stomach	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.6765
p.V51L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.V51L	NCI-H650	lung	COSMIC	GRGPLTQVT	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.R110H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667
p.R110H	ACH-001127	Leukemia	CCLE	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667
p.R110H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667
p.R110C	SIDM00975	Melanoma	GDSC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667
p.R110C	ACH-002206	Skin Cancer	CCLE	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667
p.R110C	WM278	skin	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1667

Kaplan plot for PNKP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNKP

UniProt ID: Q96T60

Entrez ID: 11284

Protein name: Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNKP in