DegronMD

Uniprot ID: Q96T60

Source protein: Bifunctional polynucleotide phosphatase/kinase

Source gene: PNKP

Class: DEG_SCF_FBW7_1

Location: 116:122

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 83.6

COIL: 0.9343

CONS_SCORE: 0.2799

DSS_SCORE: 0.8382

HELIX: 0.0144

FCONS_SCORE: 1.0699

RIG_SCORE: 0.5551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L124V	TCGA-67-3771	LUAD	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.2778
p.L124V	DO25797	LUAD	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.2778
p.S126F	TCGA-AX-A2HC	UCEC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.6667
p.S126F	DO41572	UCEC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.6667
p.P119L	TCGA-BS-A0UF	UCEC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.7582
p.P119L	DO41488	UCEC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.7582
p.P119L	ACH-001184	Sarcoma	CCLE	PDTPPGT	DEG_SCF_FBW7_1	0.7582
p.W106C	TCGA-CR-7388	HNSC	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.0556
p.W106C	TCGA-EE-A2GN	SKCM	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.0556
p.W106C	DO14284	HNSC	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.0556
p.W106C	DO37896	SKCM	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.0556
p.D117Y	TCGA-DA-A1I1	SKCM	TCGA	PDTPPGT	DEG_SCF_FBW7_1	0.6214
p.D117Y	DO37966	SKCM	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.6214
p.P112R	DO52481	COCA	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.2222
p.P119S	DO220891	MELA	ICGC	PDTPPGT	DEG_SCF_FBW7_1	0.6752
p.P119S	ACH-001184	Sarcoma	CCLE	PDTPPGT	DEG_SCF_FBW7_1	0.6752
p.S126T	SIDM01045	Endometrial Carcinoma	GDSC	PDTPPGT	DEG_SCF_FBW7_1	0.6667
p.S126T	ACH-000978	Endometrial/Uterine Cancer	CCLE	PDTPPGT	DEG_SCF_FBW7_1	0.6667
p.S126T	EN	endometrium	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	0.6667
p.R110H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PDTPPGT	DEG_SCF_FBW7_1	0.1667
p.R110H	ACH-001127	Leukemia	CCLE	PDTPPGT	DEG_SCF_FBW7_1	0.1667
p.R110H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	0.1667
p.R110C	SIDM00975	Melanoma	GDSC	PDTPPGT	DEG_SCF_FBW7_1	0.1667
p.R110C	ACH-002206	Skin Cancer	CCLE	PDTPPGT	DEG_SCF_FBW7_1	0.1667
p.R110C	WM278	skin	COSMIC	PDTPPGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T60	Bifunctional polynucleotide phosphatase/kinase	DEG_SCF_FBW7_1	116:122	PDTPPGT	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons