DegronMD

Uniprot ID: P42166

Source protein: Lamina-associated polypeptide 2, isoform alpha

Source gene: TMPO

Class: DEG_APCC_DBOX_1

Location: 263:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5787

ASA_SCORE: 88.3

COIL: 0.6207

CONS_SCORE: 0.4213

DSS_SCORE: 0.4409

HELIX: 0.2468

FCONS_SCORE: 0.9384

RIG_SCORE: 0.7433

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E267K	TCGA-05-4402	LUAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.7022
p.E267K	DO24960	LUAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7022
p.P255H	TCGA-2W-A8YY	CESC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1111
p.P255H	DO223732	CESC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1111
p.R256I	TCGA-AA-3984	COAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.R256I	TCGA-IB-7651	PAAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.R256I	DO9002	COAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.R256I	DO46657	PAAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.T257I	TCGA-AP-A059	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1667
p.T257I	DO41361	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1667
p.A261D	TCGA-AP-A1DK	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.A261D	DO42033	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.G263D	TCGA-AP-A1DV	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.G263D	DO43186	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.F262C	TCGA-B5-A0K9	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.3056
p.F262C	DO42097	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.3056
p.R256K	TCGA-B5-A11N	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.R256K	DO41458	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.L268F	TCGA-CN-4733	HNSC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6981
p.L268F	DO14894	HNSC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6981
p.E274D	TCGA-D1-A103	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.E274D	DO42312	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.P258A	TCGA-D3-A3MR	SKCM	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.P258A	DO47256	SKCM	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.P258L	TCGA-D3-A3MR	SKCM	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.P258L	DO47256	SKCM	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.F274L	TCGA-FU-A3HZ	CESC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.F274L	DO6308	CESC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.G263C	TCGA-HU-A4GU	STAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6489
p.G263C	DO47849	STAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6489
p.A271S	TCGA-X6-A7WB	SARC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6477
p.A271S	DO220314	SARC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6477
p.F277Y	DO228123	EOPC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1667
p.Q268R	DO233150	GACA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6218
p.L276F	DO228952	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.G260V	DO229029	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.R255H	DO50970	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1111
p.R269C	SIDM02035	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.8301
p.R274S	SIDM01314	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.R274K	SIDM00128	Head and Neck Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.R274K	SIDM00778	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.R274K	SIDM01000	Melanoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.25
p.E266Q	SIDM00845	Burkitt's Lymphoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	SIDM00461	Acute Myeloid Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	ACH-000786	Lymphoma	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	ACH-000992	Head and Neck Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.P273A	SIDM00845	Burkitt's Lymphoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.P273A	SIDM00461	Acute Myeloid Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.P273A	SIDM01519	Head and Neck Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.P273A	ACH-000786	Lymphoma	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.P273A	ACH-000992	Head and Neck Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.P273A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.2778
p.I270M	SIDM00850	Gastric Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.I270M	ACH-000880	Gastric Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.I270M	AGS	stomach	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.G265E	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.G265E	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.L256P	SIDM01617	Endometrial Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.P267S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6752
p.V258L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1944
p.A281T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.5
p.P278T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1389
p.G263A	NCI-H1573	lung	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6429
p.V255A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRGQLQKLA

Degron related mutations and impact score

Drug responses associated with TMPO mutations

All proteins holding degron of GRGQLQKLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42166	Lamina-associated polypeptide 2, isoform alpha	DEG_APCC_DBOX_1	263:271	GRGQLQKLA	APC,CDC20,FZR1	0.5787	More...