DegronMD

Uniprot ID: P42166

Source protein: Lamina-associated polypeptide 2, isoform alpha

Source gene: TMPO

Class: DEG_APCC_DBOX_1

Location: 263:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5787

ASA_SCORE: 88.3

COIL: 0.6207

CONS_SCORE: 0.4213

DSS_SCORE: 0.4409

HELIX: 0.2468

FCONS_SCORE: 0.9384

RIG_SCORE: 0.7433

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R269C	SIDM02035	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.8301
p.I270M	SIDM00850	Gastric Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.I270M	ACH-000880	Gastric Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.I270M	AGS	stomach	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7618
p.E267K	TCGA-05-4402	LUAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.7022
p.E267K	DO24960	LUAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.7022
p.L268F	TCGA-CN-4733	HNSC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6981
p.L268F	DO14894	HNSC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6981
p.P267S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6752
p.E266Q	SIDM00845	Burkitt's Lymphoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	SIDM00461	Acute Myeloid Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	ACH-000786	Lymphoma	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.E266Q	ACH-000992	Head and Neck Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	0.6744
p.G263C	TCGA-HU-A4GU	STAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6489
p.G263C	DO47849	STAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6489
p.A271S	TCGA-X6-A7WB	SARC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6477
p.A271S	DO220314	SARC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6477
p.G263A	NCI-H1573	lung	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6429
p.Q268R	DO233150	GACA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6218
p.G263D	TCGA-AP-A1DV	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.G263D	DO43186	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.G265E	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.G265E	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.6087
p.A281T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	0.5
p.F262C	TCGA-B5-A0K9	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	0.3056

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Drug responses associated with TMPO mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GRGQLQKLA

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42166	Lamina-associated polypeptide 2, isoform alpha	DEG_APCC_DBOX_1	263:271	GRGQLQKLA	APC,CDC20,FZR1	0.5787	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRGQLQKLA

Degron related mutations and impact score

Drug responses associated with TMPO mutations

All proteins holding degron of GRGQLQKLA