DegronMD - P42166(TMPO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E267K	TCGA-05-4402	LUAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.7022
p.E267K	DO24960	LUAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.7022
p.F218L	TCGA-18-3407	LUSC	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.F218L	DO26454	LUSC	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.P255H	TCGA-2W-A8YY	CESC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1111
p.P255H	DO223732	CESC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1111
p.R256I	TCGA-AA-3984	COAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.R256I	TCGA-IB-7651	PAAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.R256I	DO9002	COAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.R256I	DO46657	PAAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.R201G	TCGA-AG-3906	READ	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.R201G	DO36491	READ	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.T257I	TCGA-AP-A059	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.T257I	DO41361	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.A261D	TCGA-AP-A1DK	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.A261D	DO42033	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.G263D	TCGA-AP-A1DV	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6087
p.G263D	DO43186	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6087
p.E208K	TCGA-AR-A2LE	BRCA	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7022
p.E208K	DO1932	BRCA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7022
p.F262C	TCGA-B5-A0K9	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.3056
p.F262C	DO42097	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.3056
p.R256K	TCGA-B5-A11N	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.R256K	DO41458	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.S199C	TCGA-BT-A3PK	BLCA	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.S199C	DO44051	BLCA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.L268F	TCGA-CN-4733	HNSC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6981
p.L268F	DO14894	HNSC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6981
p.E274D	TCGA-D1-A103	UCEC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.E274D	DO42312	UCEC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.P258A	TCGA-D3-A3MR	SKCM	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.P258A	DO47256	SKCM	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.P258L	TCGA-D3-A3MR	SKCM	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.P258L	DO47256	SKCM	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.P213S	TCGA-EE-A29E	SKCM	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P213S	DO222504	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P213S	DO222843	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P213S	DO37831	SKCM	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P213L	TCGA-FR-A8YC	SKCM	TCGA	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.P213L	DO50301	SKCM	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.F274L	TCGA-FU-A3HZ	CESC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.F274L	DO6308	CESC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.G263C	TCGA-HU-A4GU	STAD	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6489
p.G263C	DO47849	STAD	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6489
p.A271S	TCGA-X6-A7WB	SARC	TCGA	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6477
p.A271S	DO220314	SARC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6477
p.F277Y	DO228123	EOPC	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.Q268R	DO233150	GACA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6218
p.P209Q	DO14766	HNSC	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.P209Q	DO28923	OV	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.L276F	DO228952	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.G260V	DO229029	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.G204C	DO229035	LICA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.76
p.R255H	DO50970	LICA	ICGC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1111
p.P213A	DO222875	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1944
p.A206G	SIDM02068	Esophageal Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.754
p.R269C	SIDM02035	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8301
p.R274S	SIDM01314	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.R274K	SIDM00128	Head and Neck Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.R274K	SIDM00778	Colorectal Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.R274K	SIDM01000	Melanoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.25
p.T200A	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.T200A	SIDM00461	Acute Myeloid Leukemia	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.T200A	SIDM01519	Head and Neck Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.I203F	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6304
p.I203S	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7341
p.E266Q	SIDM00845	Burkitt's Lymphoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6744
p.E266Q	SIDM00461	Acute Myeloid Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6744
p.E266Q	ACH-000786	Lymphoma	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6744
p.E266Q	ACH-000992	Head and Neck Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6744
p.P273A	SIDM00845	Burkitt's Lymphoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.P273A	SIDM00461	Acute Myeloid Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.P273A	SIDM01519	Head and Neck Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.P273A	ACH-000786	Lymphoma	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.P273A	ACH-000992	Head and Neck Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.P273A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.R205K	SIDM00660	Colorectal Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7237
p.R205K	ACH-000985	Colon/Colorectal Cancer	CCLE	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7237
p.R205K	LS-411N	large intestine	COSMIC	IVPFSE	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7237
p.I270M	SIDM00850	Gastric Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.7618
p.I270M	ACH-000880	Gastric Cancer	CCLE	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.7618
p.I270M	AGS	stomach	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.7618
p.G265E	SIDM00451	T-Lymphoblastic Leukemia	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6087
p.G265E	PF-382	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6087
p.L256P	SIDM01617	Endometrial Carcinoma	GDSC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.P267S	Daudi	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6752
p.V258L	Daudi	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.A281T	Daudi	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation blocking ubiquitination signal	0.5
p.P278T	Daudi	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.G263A	NCI-H1573	lung	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6429
p.V255A	Daudi	haematopoietic and lymphoid tissue	COSMIC	GRGQLQKLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMPO

UniProt ID: P42166

Entrez ID: 7112

Protein name: Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TMPO in