DegronMD

Uniprot ID: P42166

Source protein: Lamina-associated polypeptide 2, isoform alpha

Source gene: TMPO

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9672

ASA_SCORE: 98

COIL: 0.8668

CONS_SCORE: 0.491

DSS_SCORE: 0.5632

HELIX: 0.0442

FCONS_SCORE: 0.9086

RIG_SCORE: 0.767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F218L	TCGA-18-3407	LUSC	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.0556
p.F218L	DO26454	LUSC	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.0556
p.R201G	TCGA-AG-3906	READ	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.2778
p.R201G	DO36491	READ	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.2778
p.E208K	TCGA-AR-A2LE	BRCA	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.7022
p.E208K	DO1932	BRCA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.7022
p.S199C	TCGA-BT-A3PK	BLCA	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.2222
p.S199C	DO44051	BLCA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.2222
p.P213S	TCGA-EE-A29E	SKCM	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P213S	DO222504	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P213S	DO222843	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P213S	DO37831	SKCM	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P213L	TCGA-FR-A8YC	SKCM	TCGA	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P213L	DO50301	SKCM	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.P209Q	DO14766	HNSC	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.3056
p.P209Q	DO28923	OV	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.3056
p.G204C	DO229035	LICA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.76
p.P213A	DO222875	MELA	ICGC	IVPFSE	LIG_APCC_ABBA_1	0.1944
p.A206G	SIDM02068	Esophageal Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.754
p.T200A	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.25
p.T200A	SIDM00461	Acute Myeloid Leukemia	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.25
p.T200A	SIDM01519	Head and Neck Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.25
p.I203F	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.6304
p.I203S	SIDM00845	Burkitt's Lymphoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.7341
p.R205K	SIDM00660	Colorectal Carcinoma	GDSC	IVPFSE	LIG_APCC_ABBA_1	0.7237
p.R205K	ACH-000985	Colon/Colorectal Cancer	CCLE	IVPFSE	LIG_APCC_ABBA_1	0.7237
p.R205K	LS-411N	large_intestine	COSMIC	IVPFSE	LIG_APCC_ABBA_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42166	Lamina-associated polypeptide 2, isoform alpha	LIG_APCC_ABBA_1	203:208	IVPFSE	APC,CDC20,FZR1	0.9672	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IVPFSE

Degron related mutations and impact score

Drug responses associated with TMPO mutations

All proteins holding degron of IVPFSE