DegronMD

Uniprot ID: O43559

Source protein: Fibroblast growth factor receptor substrate 3

Source gene: FRS3

Class: DEG_APCC_DBOX_1

Location: 205:213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.829

ASA_SCORE: 82.8556

COIL: 0.8672

CONS_SCORE: 0.4169

DSS_SCORE: 0.7093

HELIX: 0.0584

FCONS_SCORE: 1.0917

RIG_SCORE: 0.6596

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R206C	TCGA-AX-A1C9	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.8301
p.R206C	TCGA-D1-A17H	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.8301
p.R206C	DO43098	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.8301
p.R206C	DO41847	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.8301
p.H207R	TCGA-DU-6392	LGG	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.7133
p.H207R	DO22237	LGG	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.7133
p.Q210L	DO229211	THCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.6654
p.H207Q	DO228952	LICA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.647
p.E214K	TCGA-IG-A3Y9	ESCA	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.3056
p.E214Q	DO1076	BRCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.3056
p.F219C	TCGA-BS-A0TC	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.1667
p.F219C	DO42400	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1667
p.F219V	DO229275	THCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1667
p.P221L	TCGA-32-2616	GBM	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.P221L	DO13462	GBM	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.P221L	SIDM00375	Head and Neck Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.P221L	SIDM01728	Endometrial Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.P221L	SIDM01735	Biliary Tract Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.P221L	SIDM01682	Gastric Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	0.1111
p.A223S	DO228924	LICA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	0.0556
p.A223S	SIDM00120	Prostate Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	0.0556
p.A223S	ACH-000979	Prostate Cancer	CCLE	GRHCLQPLP	DEG_APCC_DBOX_1	0.0556
p.A223S	DU-145	prostate	COSMIC	GRHCLQPLP	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43559	Fibroblast growth factor receptor substrate 3	DEG_APCC_DBOX_1	205:213	GRHCLQPLP	APC,CDC20,FZR1	0.829	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons