DegronMD - O43559(FRS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P221L	TCGA-32-2616	GBM	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P221L	DO13462	GBM	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P221L	SIDM00375	Head and Neck Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P221L	SIDM01728	Endometrial Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P221L	SIDM01735	Biliary Tract Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P221L	SIDM01682	Gastric Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P185T	TCGA-AJ-A3EK	UCEC	TCGA	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation rewiring degron network	0.1111
p.P185T	DO41584	UCEC	ICGC	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation rewiring degron network	0.1111
p.R206C	TCGA-AX-A1C9	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.8301
p.R206C	TCGA-D1-A17H	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.8301
p.R206C	DO43098	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.8301
p.R206C	DO41847	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.8301
p.F219C	TCGA-BS-A0TC	UCEC	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1667
p.F219C	DO42400	UCEC	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1667
p.H207R	TCGA-DU-6392	LGG	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.7133
p.H207R	DO22237	LGG	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.7133
p.E214K	TCGA-IG-A3Y9	ESCA	TCGA	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.3056
p.P196L	TCGA-P3-A6T5	HNSC	TCGA	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation altering degron motif	0.7582
p.P196L	DO49066	HNSC	ICGC	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation altering degron motif	0.7582
p.E214Q	DO1076	BRCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.3056
p.E187K	DO222848	BTCA	ICGC	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation rewiring degron network	0.1667
p.A223S	DO228924	LICA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.A223S	SIDM00120	Prostate Carcinoma	GDSC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.A223S	ACH-000979	Prostate Cancer	CCLE	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.A223S	DU-145	prostate	COSMIC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.H207Q	DO228952	LICA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.647
p.F219V	DO229275	THCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1667
p.Q210L	DO229211	THCA	ICGC	GRHCLQPLP	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6654
p.A184V	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation rewiring degron network	0.0833
p.A184V	ACH-000379	Lung Cancer	CCLE	VNTPASE	DEG_SCF_FBW7_2	193:199	Mutation rewiring degron network	0.0833

Kaplan plot for FRS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRS3

UniProt ID: O43559

Entrez ID: 10817

Protein name: Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRS3 in