DegronMD

Uniprot ID: O43559

Source protein: Fibroblast growth factor receptor substrate 3

Source gene: FRS3

Class: DEG_SCF_FBW7_2

Location: 193:199

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 78.4143

COIL: 0.8106

CONS_SCORE: 0.5039

DSS_SCORE: 0.7208

HELIX: 0.0611

FCONS_SCORE: 1.2539

RIG_SCORE: 0.6304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185T	TCGA-AJ-A3EK	UCEC	TCGA	VNTPASE	DEG_SCF_FBW7_2	0.1111
p.P185T	DO41584	UCEC	ICGC	VNTPASE	DEG_SCF_FBW7_2	0.1111
p.P196L	TCGA-P3-A6T5	HNSC	TCGA	VNTPASE	DEG_SCF_FBW7_2	0.7582
p.P196L	DO49066	HNSC	ICGC	VNTPASE	DEG_SCF_FBW7_2	0.7582
p.E187K	DO222848	BTCA	ICGC	VNTPASE	DEG_SCF_FBW7_2	0.1667
p.A184V	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	VNTPASE	DEG_SCF_FBW7_2	0.0833
p.A184V	ACH-000379	Lung Cancer	CCLE	VNTPASE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43559	Fibroblast growth factor receptor substrate 3	DEG_SCF_FBW7_2	193:199	VNTPASE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons