DegronMD

Uniprot ID: Q99996

Source protein: A-kinase anchor protein 9

Source gene: AKAP9

Class: DEG_APCC_DBOX_1

Location: 1750:1758

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5132

ASA_SCORE: 82.1333

COIL: 0.1513

CONS_SCORE: 0.5129

DSS_SCORE: 0.2198

HELIX: 0.8543

FCONS_SCORE: 1.1805

RIG_SCORE: 0.8566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1751C	TCGA-AA-A010	COAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.8301
p.T1742A	TCGA-B5-A11E	UCEC	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.1111
p.L1754F	TCGA-EB-A431	SKCM	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.6981
p.L1754F	DO37671	SKCM	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.6981
p.S1766Y	TCGA-HV-A7OP	PAAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.1111
p.R1751L	TCGA-KK-A59X	PRAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.8428
p.R1751L	DO51348	PRAD	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.8428
p.S1760Y	TCGA-YC-A89H	BLCA	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	0.2778
p.S1760Y	DO51948	BLCA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.2778
p.R1763H	DO231147	LAML	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.1944
p.V1750F	DO229019	LICA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.7068
p.V1753F	DO229028	LICA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.5957
p.L1747F	DO219503	SKCM	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.25
p.T1754A	DO41644	UCEC	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	0.7139
p.A1744V	SIDM00499	Prostate Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	0.1667
p.A1744V	ACH-000956	Prostate Cancer	CCLE	GRHVLGILD	DEG_APCC_DBOX_1	0.1667
p.A1744V	22RV1	prostate	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	0.1667
p.R1751H	SIDM00650	Small Cell Lung Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	0.8244
p.R1751H	SIDM01681	Non-Cancerous	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	0.8244
p.R1751H	ACH-002362	Non-Cancerous	CCLE	GRHVLGILD	DEG_APCC_DBOX_1	0.8244
p.K1762E	SIDM01187	Breast Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	0.3333
p.K1762E	UACC-812	breast	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	0.3333
p.A1755V	22RV1	prostate	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99996	A-kinase anchor protein 9	DEG_APCC_DBOX_1	1750:1758	GRHVLGILD	APC,CDC20,FZR1	0.5132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons