DegronMD - Q99996(AKAP9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D3811E	TCGA-04-1343	OV	TCGA	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.0833
p.H1784Y	TCGA-18-3409	LUSC	TCGA	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.6118
p.H1784Y	DO26444	LUSC	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.6118
p.G3103V	TCGA-22-1011	LUSC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1111
p.R3832C	TCGA-55-A57B	LUAD	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.3056
p.R3832C	TCGA-55-A57B	LUAD	TCGA	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1389
p.A3099T	TCGA-A5-A1OF	UCEC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.2222
p.R1751C	TCGA-AA-A010	COAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8301
p.I3094M	TCGA-AJ-A3EL	UCEC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation altering degron motif	0.6507
p.T1742A	TCGA-B5-A11E	UCEC	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1111
p.P3843L	TCGA-BP-5189	KIRC	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.2778
p.Y3823C	TCGA-BR-4361	STAD	TCGA	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation altering degron motif	0.8198
p.R3849M	TCGA-D3-A2JP	SKCM	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1111
p.Q3847H	TCGA-DK-A3IS	BLCA	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1667
p.L1754F	TCGA-EB-A431	SKCM	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.6981
p.L1754F	DO37671	SKCM	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.6981
p.G3103C	TCGA-EE-A17Z	SKCM	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1111
p.S1781L	TCGA-EE-A181	SKCM	TCGA	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.6556
p.S1781L	DO37444	SKCM	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.6556
p.P3845L	TCGA-HT-7475	LGG	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.2222
p.S1766Y	TCGA-HV-A7OP	PAAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1111
p.R1751L	TCGA-KK-A59X	PRAD	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8428
p.R1751L	DO51348	PRAD	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8428
p.R3834T	TCGA-P3-A5Q5	HNSC	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation altering degron motif	0.7876
p.E3825K	TCGA-VS-A958	CESC	TCGA	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation altering degron motif	0.7022
p.S1760Y	TCGA-YC-A89H	BLCA	TCGA	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.2778
p.S1760Y	DO51948	BLCA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.2778
p.D3821V	DO48451	BLCA	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation altering degron motif	0.7785
p.Q3082E	DO465	BLCA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1944
p.D3823N	DO2401	BRCA	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation altering degron motif	0.6932
p.R1763H	DO231147	LAML	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1944
p.Q3080H	DO229018	LICA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1389
p.V1750F	DO229019	LICA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.7068
p.V1753F	DO229028	LICA	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.5957
p.R3839L	DO229034	LICA	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation altering degron motif	0.8428
p.S3105I	DO229041	LICA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation substituting flanking lysine	0.1667
p.G3810C	DO229045	LICA	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.0556
p.T3831I	DO24307	LUAD	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.2778
p.T3831I	DO24307	LUAD	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1667
p.D3828E	DO26486	LUSC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1944
p.D3828E	DO26486	LUSC	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.25
p.S1778Y	DO223711	PAAD	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.2778
p.Q3077H	DO34128	PACA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.0556
p.G3846C	DO38033	SKCM	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1944
p.L1747F	DO219503	SKCM	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.25
p.I3843M	DO47819	STAD	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.2778
p.F3851C	DO41020	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.0556
p.F3851C	DO42568	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.0556
p.T1754A	DO41644	UCEC	ICGC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.7139
p.R3832W	DO41903	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.3056
p.R3832W	DO41903	UCEC	ICGC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1389
p.A1744V	SIDM00499	Prostate Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1667
p.A1744V	ACH-000956	Prostate Cancer	CCLE	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1667
p.A1744V	22RV1	prostate	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation rewiring degron network	0.1667
p.R3832H	SIDM00373	Endometrial Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.3056
p.R3832H	SIDM00373	Endometrial Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1389
p.V1790G	SIDM00915	Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.2222
p.V1790G	SIDM00741	Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.2222
p.V1790G	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.2222
p.V1790G	SIDM01229	Neuroblastoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.2222
p.R3827S	SIDM00776	Colorectal Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1667
p.R3827S	SIDM00776	Colorectal Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.2778
p.R3827S	ACH-000501	Colon/Colorectal Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1667
p.R3827S	ACH-000501	Colon/Colorectal Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.2778
p.R3827S	LS-123	large intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1667
p.R3827S	LS-123	large intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.2778
p.H3828L	SIDM00776	Colorectal Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1944
p.H3828L	SIDM00776	Colorectal Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.25
p.H3828L	ACH-000501	Colon/Colorectal Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1944
p.H3828L	ACH-000501	Colon/Colorectal Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.25
p.H3828L	LS-123	large intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.1944
p.H3828L	LS-123	large intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.25
p.R1751H	SIDM00650	Small Cell Lung Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8244
p.R1751H	SIDM01681	Non-Cancerous	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8244
p.R1751H	ACH-002362	Non-Cancerous	CCLE	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.8244
p.H1784R	SIDM00907	Burkitt's Lymphoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.8244
p.H1784R	ACH-000440	Lymphoma	CCLE	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.8244
p.H1784R	CA46	haematopoietic and lymphoid tissue	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.8244
p.K1762E	SIDM01187	Breast Carcinoma	GDSC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation substituting flanking lysine	0.3333
p.K1762E	UACC-812	breast	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation substituting flanking lysine	0.3333
p.T3830M	SIDM01502	Endometrial Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.25
p.T3830M	SIDM01502	Endometrial Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1944
p.T3830M	ACH-000435	Endometrial/Uterine Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.25
p.T3830M	ACH-000435	Endometrial/Uterine Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1944
p.N3102S	SIDM01445	Gastric Carcinoma	GDSC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1389
p.N3102S	ACH-000736	Gastric Cancer	CCLE	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.1389
p.E1786G	ACH-001369	Ovarian Cancer	CCLE	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation altering degron motif	0.7199
p.K1773E	UACC-812	breast	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.1389
p.K3078N	YH-13	central nervous system	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.0833
p.K3078N	SNU-C2B	large intestine	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.0833
p.K3078N	JHH-4	liver	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.0833
p.K3078N	LC4-1	haematopoietic and lymphoid tissue	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	3087:3095	Mutation rewiring degron network	0.0833
p.A1755V	22RV1	prostate	COSMIC	GRHVLGILD	DEG_APCC_DBOX_1	1750:1758	Mutation altering degron motif	0.6936
p.H3831L	LS-123	large intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.2778
p.H3831L	LS-123	large intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1667
p.H1795R	CA46	haematopoietic and lymphoid tissue	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	1780:1786	Mutation rewiring degron network	0.0833
p.R3830S	LS-123	large intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	3833:3841	Mutation rewiring degron network	0.25
p.R3830S	LS-123	large intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	3820:3825	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP9

UniProt ID: Q99996

Entrez ID: 10142

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP9 in