DegronMD

Uniprot ID: Q99996

Source protein: A-kinase anchor protein 9

Source gene: AKAP9

Class: LIG_APCC_ABBA_1

Location: 3820:3825

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9783

ASA_SCORE: 89

COIL: 0.7865

CONS_SCORE: 0.374

DSS_SCORE: 0.4425

HELIX: 0.1048

FCONS_SCORE: 1.0457

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3811E	TCGA-04-1343	OV	TCGA	LELYGE	LIG_APCC_ABBA_1	0.0833
p.R3832C	TCGA-55-A57B	LUAD	TCGA	LELYGE	LIG_APCC_ABBA_1	0.1389
p.Y3823C	TCGA-BR-4361	STAD	TCGA	LELYGE	LIG_APCC_ABBA_1	0.8198
p.E3825K	TCGA-VS-A958	CESC	TCGA	LELYGE	LIG_APCC_ABBA_1	0.7022
p.D3821V	DO48451	BLCA	ICGC	LELYGE	LIG_APCC_ABBA_1	0.7785
p.D3823N	DO2401	BRCA	ICGC	LELYGE	LIG_APCC_ABBA_1	0.6932
p.G3810C	DO229045	LICA	ICGC	LELYGE	LIG_APCC_ABBA_1	0.0556
p.T3831I	DO24307	LUAD	ICGC	LELYGE	LIG_APCC_ABBA_1	0.1667
p.D3828E	DO26486	LUSC	ICGC	LELYGE	LIG_APCC_ABBA_1	0.25
p.R3832W	DO41903	UCEC	ICGC	LELYGE	LIG_APCC_ABBA_1	0.1389
p.R3832H	SIDM00373	Endometrial Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	0.1389
p.R3827S	SIDM00776	Colorectal Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	0.2778
p.R3827S	ACH-000501	Colon/Colorectal Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	0.2778
p.R3827S	LS-123	large_intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	0.2778
p.H3828L	SIDM00776	Colorectal Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	0.25
p.H3828L	ACH-000501	Colon/Colorectal Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	0.25
p.H3828L	LS-123	large_intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	0.25
p.T3830M	SIDM01502	Endometrial Carcinoma	GDSC	LELYGE	LIG_APCC_ABBA_1	0.1944
p.T3830M	ACH-000435	Endometrial/Uterine Cancer	CCLE	LELYGE	LIG_APCC_ABBA_1	0.1944
p.H3831L	LS-123	large_intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	0.1667
p.R3830S	LS-123	large_intestine	COSMIC	LELYGE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99996	A-kinase anchor protein 9	LIG_APCC_ABBA_1	3820:3825	LELYGE	APC,CDC20,FZR1	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons