DegronMD

Uniprot ID: Q99996

Source protein: A-kinase anchor protein 9

Source gene: AKAP9

Class: DEG_APCC_DBOX_1

Location: 3833:3841

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9906

ASA_SCORE: 90.6778

COIL: 0.8367

CONS_SCORE: 0.441

DSS_SCORE: 0.4666

HELIX: 0.1163

FCONS_SCORE: 1.1518

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3832C	TCGA-55-A57B	LUAD	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.3056
p.P3843L	TCGA-BP-5189	KIRC	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.2778
p.R3849M	TCGA-D3-A2JP	SKCM	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.1111
p.Q3847H	TCGA-DK-A3IS	BLCA	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.1667
p.P3845L	TCGA-HT-7475	LGG	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.2222
p.R3834T	TCGA-P3-A5Q5	HNSC	TCGA	SRSDLDYIR	DEG_APCC_DBOX_1	0.7876
p.R3839L	DO229034	LICA	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.8428
p.T3831I	DO24307	LUAD	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.2778
p.D3828E	DO26486	LUSC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1944
p.G3846C	DO38033	SKCM	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1944
p.I3843M	DO47819	STAD	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.2778
p.F3851C	DO41020	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.0556
p.F3851C	DO42568	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.0556
p.R3832W	DO41903	UCEC	ICGC	SRSDLDYIR	DEG_APCC_DBOX_1	0.3056
p.R3832H	SIDM00373	Endometrial Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	0.3056
p.R3827S	SIDM00776	Colorectal Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1667
p.R3827S	ACH-000501	Colon/Colorectal Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	0.1667
p.R3827S	LS-123	large_intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1667
p.H3828L	SIDM00776	Colorectal Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1944
p.H3828L	ACH-000501	Colon/Colorectal Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	0.1944
p.H3828L	LS-123	large_intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	0.1944
p.T3830M	SIDM01502	Endometrial Carcinoma	GDSC	SRSDLDYIR	DEG_APCC_DBOX_1	0.25
p.T3830M	ACH-000435	Endometrial/Uterine Cancer	CCLE	SRSDLDYIR	DEG_APCC_DBOX_1	0.25
p.H3831L	LS-123	large_intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	0.2778
p.R3830S	LS-123	large_intestine	COSMIC	SRSDLDYIR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99996	A-kinase anchor protein 9	DEG_APCC_DBOX_1	3833:3841	SRSDLDYIR	APC,CDC20,FZR1	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSDLDYIR

Degron related mutations and impact score

Drug responses associated with AKAP9 mutations

All proteins holding degron of SRSDLDYIR