DegronMD

Uniprot ID: Q99996

Source protein: A-kinase anchor protein 9

Source gene: AKAP9

Class: LIG_APCC_ABBAyCdc20_2

Location: 1780:1786

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.733

ASA_SCORE: 102.3

COIL: 0.365

CONS_SCORE: 0.303

DSS_SCORE: 0.4627

HELIX: 0.6216

FCONS_SCORE: 0.9796

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1784Y	TCGA-18-3409	LUSC	TCGA	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H1784Y	DO26444	LUSC	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.6118
p.S1781L	TCGA-EE-A181	SKCM	TCGA	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.6556
p.S1781L	DO37444	SKCM	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.6556
p.S1778Y	DO223711	PAAD	ICGC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V1790G	SIDM00915	Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V1790G	SIDM00741	Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V1790G	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V1790G	SIDM01229	Neuroblastoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H1784R	SIDM00907	Burkitt's Lymphoma	GDSC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.8244
p.H1784R	ACH-000440	Lymphoma	CCLE	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.8244
p.H1784R	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.8244
p.E1786G	ACH-001369	Ovarian Cancer	CCLE	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.7199
p.K1773E	UACC-812	breast	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.H1795R	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	KSCVHEE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99996	A-kinase anchor protein 9	LIG_APCC_ABBAyCdc20_2	1780:1786	KSCVHEE	APC,CDC20,FZR1	0.733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons