DegronMD

Uniprot ID: Q99996

Source protein: A-kinase anchor protein 9

Source gene: AKAP9

Class: DEG_APCC_DBOX_1

Location: 3087:3095

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9888

ASA_SCORE: 97.7222

COIL: 0.0394

CONS_SCORE: 0.5814

DSS_SCORE: 0.308

HELIX: 0.9612

FCONS_SCORE: 1.2312

RIG_SCORE: 0.7752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3103V	TCGA-22-1011	LUSC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1111
p.A3099T	TCGA-A5-A1OF	UCEC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	0.2222
p.I3094M	TCGA-AJ-A3EL	UCEC	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	0.6507
p.G3103C	TCGA-EE-A17Z	SKCM	TCGA	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1111
p.Q3082E	DO465	BLCA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1944
p.Q3080H	DO229018	LICA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1389
p.S3105I	DO229041	LICA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1667
p.Q3077H	DO34128	PACA	ICGC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.0556
p.N3102S	SIDM01445	Gastric Carcinoma	GDSC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1389
p.N3102S	ACH-000736	Gastric Cancer	CCLE	RRSLLSEIQ	DEG_APCC_DBOX_1	0.1389
p.K3078N	YH-13	central_nervous_system	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.0833
p.K3078N	SNU-C2B	large_intestine	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.0833
p.K3078N	JHH-4	liver	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.0833
p.K3078N	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRSLLSEIQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99996	A-kinase anchor protein 9	DEG_APCC_DBOX_1	3087:3095	RRSLLSEIQ	APC,CDC20,FZR1	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons