DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_APCC_DBOX_1

Location: 1352:1360

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9834

ASA_SCORE: 73.2778

COIL: 0.8256

CONS_SCORE: 0.3223

DSS_SCORE: 0.448

HELIX: 0.0177

FCONS_SCORE: 1.1038

RIG_SCORE: 0.7585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1359L	TCGA-44-7670	LUAD	TCGA	GRIILPNVN	DEG_APCC_DBOX_1	0.5654
p.G1349R	TCGA-AN-A046	BRCA	TCGA	GRIILPNVN	DEG_APCC_DBOX_1	0.25
p.D1362H	TCGA-MT-A67F	HNSC	TCGA	GRIILPNVN	DEG_APCC_DBOX_1	0.2778
p.D1343N	DO48457	BLCA	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.0833
p.E1358Q	DO49759	BLCA	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.6744
p.K1348T	DO8730	COAD	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.2222
p.K1344T	DO8264	COAD	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.2222
p.K1344T	DO41799	UCEC	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.2222
p.V1356A	DO52438	COCA	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.6936
p.T1346S	DO228067	EOPC	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.1667
p.A1369T	DO50970	LICA	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.0833
p.I1360S	DO46897	RECA	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.7341
p.E1358D	DO43186	UCEC	ICGC	GRIILPNVN	DEG_APCC_DBOX_1	0.6758
p.H1365D	SIDM00562	Breast Carcinoma	GDSC	GRIILPNVN	DEG_APCC_DBOX_1	0.1944
p.H1365D	ACH-002163	Breast Cancer	CCLE	GRIILPNVN	DEG_APCC_DBOX_1	0.1944
p.H1365D	MRK-nu-1	breast	COSMIC	GRIILPNVN	DEG_APCC_DBOX_1	0.1944
p.G1352R	ACH-000923	Lymphoma	CCLE	GRIILPNVN	DEG_APCC_DBOX_1	0.6457
p.H1365L	SW1710	urinary_tract	COSMIC	GRIILPNVN	DEG_APCC_DBOX_1	0.1944
p.V1351L	KMH-2	thyroid	COSMIC	GRIILPNVN	DEG_APCC_DBOX_1	0.3056
p.S1360R	SCC-9	upper_aerodigestive_tract	COSMIC	GRIILPNVN	DEG_APCC_DBOX_1	0.7427
p.N1349H	HT-115	large_intestine	COSMIC	GRIILPNVN	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_APCC_DBOX_1	1352:1360	GRIILPNVN	APC,CDC20,FZR1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons