DegronMD

Uniprot ID: Q9Y3D5

Source protein: 28S ribosomal protein S18c, mitochondrial

Source gene: MRPS18C

Class: DEG_APCC_DBOX_1

Location: 12:20

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8924

ASA_SCORE: 95.5556

COIL: 0.5576

CONS_SCORE: 0.4531

DSS_SCORE: 0.106

HELIX: 0.0913

FCONS_SCORE: 1.3925

RIG_SCORE: 0.8324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A22T	TCGA-55-7815	LUAD	TCGA	GRKKLTHLV	DEG_APCC_DBOX_1	0.2778
p.A22T	DO24537	LUAD	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.2778
p.L16S	TCGA-EE-A3J7	SKCM	TCGA	GRKKLTHLV	DEG_APCC_DBOX_1	0.7667
p.L16S	DO48770	SKCM	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.7667
p.G9S	TCGA-UY-A9PE	BLCA	TCGA	GRKKLTHLV	DEG_APCC_DBOX_1	0.25
p.G9S	DO219043	BLCA	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.25
p.G9V	TCGA-UY-A9PE	BLCA	TCGA	GRKKLTHLV	DEG_APCC_DBOX_1	0.25
p.G9V	DO219043	BLCA	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.25
p.A23V	DO234150	ESAD	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.25
p.V24F	DO228974	LICA	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.2222
p.G10V	DO229036	LICA	ICGC	GRKKLTHLV	DEG_APCC_DBOX_1	0.2778
p.P29S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	GRKKLTHLV	DEG_APCC_DBOX_1	0.0833
p.P29S	ACH-000809	Esophageal Cancer	CCLE	GRKKLTHLV	DEG_APCC_DBOX_1	0.0833
p.P29S	KYSE-410	oesophagus	COSMIC	GRKKLTHLV	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3D5	28S ribosomal protein S18c, mitochondrial	DEG_APCC_DBOX_1	12:20	GRKKLTHLV	APC,CDC20,FZR1	0.8924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons