DegronMD

Uniprot ID: Q8WXS8

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 14

Source gene: ADAMTS14

Class: DEG_APCC_DBOX_1

Location: 588:596

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6982

ASA_SCORE: 70.0333

COIL: 0.6997

CONS_SCORE: 0.5526

DSS_SCORE: 0.0938

HELIX: 0.021

FCONS_SCORE: 0.8664

RIG_SCORE: 0.7825

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E600D	TCGA-A2-A25A	BRCA	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.E600D	DO3101	BRCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.S586F	TCGA-FW-A3R5	SKCM	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	0.2778
p.S586F	DO37406	SKCM	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2778
p.S586F	SIDM00327	Hodgkin's Lymphoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2778
p.S586F	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2778
p.R580W	TCGA-HU-A4GQ	STAD	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	0.1111
p.R580W	DO47767	STAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.1111
p.R592C	TCGA-IB-7651	PAAD	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	0.8301
p.R592C	DO46657	PAAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.8301
p.L593P	DO229010	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7582
p.L593P	DO229013	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7582
p.L593P	DO229016	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7582
p.L593P	DO229003	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7582
p.L593P	DO229005	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7582
p.R580Q	DO234190	ESAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.1111
p.V603F	DO229019	LICA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.1389
p.S606I	DO229035	LICA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.S579N	DO229224	THCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0833
p.R578C	SIDM00781	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578C	SIDM00780	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578C	ACH-000967	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578C	ACH-001199	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578C	SNU-C2B	large_intestine	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.E600K	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.E600K	SIDM00158	Glioblastoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.E600K	ACH-000623	Brain Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.E600K	ACH-002221	Lymphoma	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.E600K	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.2222
p.R578H	SIDM00118	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578H	SIDM01770	Gastric Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578H	ACH-000908	Gastric Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578H	ACH-001081	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.R578H	HCC2998	large_intestine	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.0556
p.G591D	SIDM01729	Endometrial Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.7198
p.G591D	ACH-000909	Endometrial/Uterine Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.7198
p.Y601C	SIDM01619	Endometrial Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	0.1944
p.Y601C	ACH-000984	Endometrial/Uterine Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	0.1944
p.E597K	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.3056
p.S583F	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRLCLGPMF

Degron related mutations and impact score

Drug responses associated with ADAMTS14 mutations

All proteins holding degron of GRLCLGPMF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXS8	A disintegrin and metalloproteinase with thrombospondin motifs 14	DEG_APCC_DBOX_1	588:596	GRLCLGPMF	APC,CDC20,FZR1	0.6982	More...