DegronMD - Q8WXS8(ADAMTS14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E600D	TCGA-A2-A25A	BRCA	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.E600D	DO3101	BRCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.Q1196K	TCGA-D3-A2J6	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation altering degron motif	0.6944
p.Q1196K	DO37901	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation altering degron motif	0.6944
p.T1199M	TCGA-D7-A6F2	STAD	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation altering degron motif	0.7423
p.T1199M	DO50121	STAD	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation altering degron motif	0.7423
p.P1202A	TCGA-E7-A3Y1	BLCA	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.2778
p.P1202A	DO528	BLCA	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.2778
p.W1192C	TCGA-EE-A184	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.25
p.W1192C	TCGA-ER-A19F	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.25
p.W1192C	DO37679	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.25
p.W1192C	DO47442	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.25
p.T1186S	TCGA-EY-A1GK	UCEC	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.0833
p.T1186S	DO42985	UCEC	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.0833
p.S586F	TCGA-FW-A3R5	SKCM	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.S586F	DO37406	SKCM	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.S586F	SIDM00327	Hodgkin's Lymphoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.S586F	L-428	haematopoietic and lymphoid tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2778
p.G1189E	TCGA-GN-A266	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1667
p.G1189E	DO37432	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1667
p.R580W	TCGA-HU-A4GQ	STAD	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.R580W	DO47767	STAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.R592C	TCGA-IB-7651	PAAD	TCGA	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8301
p.R592C	DO46657	PAAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.8301
p.G1189V	TCGA-MI-A75E	LIHC	TCGA	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1667
p.G1189V	DO49707	LIHC	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1667
p.L593P	DO229010	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7582
p.L593P	DO229013	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7582
p.L593P	DO229016	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7582
p.L593P	DO229003	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7582
p.L593P	DO229005	COCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7582
p.R580Q	DO234190	ESAD	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1111
p.G1206V	DO228974	LICA	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1667
p.V603F	DO229019	LICA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1389
p.S606I	DO229035	LICA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.P1187S	DO220898	MELA	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1111
p.P1191L	DO220911	MELA	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.2222
p.G1188R	DO229112	PRAD	ICGC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1389
p.G1188R	SIDM00945	Colorectal Carcinoma	GDSC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1389
p.S579N	DO229224	THCA	ICGC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0833
p.P1187L	SIDM00684	Glioblastoma	GDSC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1111
p.P1187L	ACH-000595	Brain Cancer	CCLE	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1111
p.P1187L	LN-229	central nervous system	COSMIC	PTPVPE	DEG_SCF_FBW7_2	1195:1200	Mutation rewiring degron network	0.1111
p.R578C	SIDM00781	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578C	SIDM00780	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578C	ACH-000967	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578C	ACH-001199	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578C	SNU-C2B	large intestine	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.E600K	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.E600K	SIDM00158	Glioblastoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.E600K	ACH-000623	Brain Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.E600K	ACH-002221	Lymphoma	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.E600K	CTB-1	haematopoietic and lymphoid tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.2222
p.R578H	SIDM00118	Colorectal Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578H	SIDM01770	Gastric Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578H	ACH-000908	Gastric Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578H	ACH-001081	Colon/Colorectal Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.R578H	HCC2998	large intestine	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.0556
p.G591D	SIDM01729	Endometrial Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7198
p.G591D	ACH-000909	Endometrial/Uterine Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation altering degron motif	0.7198
p.Y601C	SIDM01619	Endometrial Carcinoma	GDSC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.Y601C	ACH-000984	Endometrial/Uterine Cancer	CCLE	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944
p.E597K	CTB-1	haematopoietic and lymphoid tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.3056
p.S583F	L-428	haematopoietic and lymphoid tissue	COSMIC	GRLCLGPMF	DEG_APCC_DBOX_1	588:596	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS14

UniProt ID: Q8WXS8

Entrez ID: 140766

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS14 in