DegronMD

Uniprot ID: Q8WXS8

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 14

Source gene: ADAMTS14

Class: DEG_SCF_FBW7_2

Location: 1195:1200

E3 ligase: FBXW7

DEGRON score: 0.6825

ASA_SCORE: 93.1167

COIL: 0.954

CONS_SCORE: 0.2472

DSS_SCORE: 0.7804

HELIX: 0.0228

FCONS_SCORE: 1.0034

RIG_SCORE: 0.6767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1196K	TCGA-D3-A2J6	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.6944
p.Q1196K	DO37901	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.6944
p.T1199M	TCGA-D7-A6F2	STAD	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.7423
p.T1199M	DO50121	STAD	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.7423
p.P1202A	TCGA-E7-A3Y1	BLCA	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.2778
p.P1202A	DO528	BLCA	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.2778
p.W1192C	TCGA-EE-A184	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.25
p.W1192C	TCGA-ER-A19F	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.25
p.W1192C	DO37679	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.25
p.W1192C	DO47442	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.25
p.T1186S	TCGA-EY-A1GK	UCEC	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.0833
p.T1186S	DO42985	UCEC	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.0833
p.G1189E	TCGA-GN-A266	SKCM	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.1667
p.G1189E	DO37432	SKCM	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.1667
p.G1189V	TCGA-MI-A75E	LIHC	TCGA	PTPVPE	DEG_SCF_FBW7_2	0.1667
p.G1189V	DO49707	LIHC	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.1667
p.G1206V	DO228974	LICA	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.1667
p.P1187S	DO220898	MELA	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.1111
p.P1191L	DO220911	MELA	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.2222
p.G1188R	DO229112	PRAD	ICGC	PTPVPE	DEG_SCF_FBW7_2	0.1389
p.G1188R	SIDM00945	Colorectal Carcinoma	GDSC	PTPVPE	DEG_SCF_FBW7_2	0.1389
p.P1187L	SIDM00684	Glioblastoma	GDSC	PTPVPE	DEG_SCF_FBW7_2	0.1111
p.P1187L	ACH-000595	Brain Cancer	CCLE	PTPVPE	DEG_SCF_FBW7_2	0.1111
p.P1187L	LN-229	central_nervous_system	COSMIC	PTPVPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXS8	A disintegrin and metalloproteinase with thrombospondin motifs 14	DEG_SCF_FBW7_2	1195:1200	PTPVPE	FBXW7	0.6825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons