DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GRLELGDVE
Uniprot ID:
A4D1U4
Source protein:
DENN domain-containing protein 11
Source gene:
DENND11
Class:
DEG_APCC_DBOX_1
Location:
65:73
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5555
ASA_SCORE:
87.1
COIL:
0.7397
CONS_SCORE:
0.2764
DSS_SCORE:
0.398
HELIX:
0.1213
FCONS_SCORE:
0.6923
RIG_SCORE:
0.7356
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DENND11 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRLELGDVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A4D1U4
DENN domain-containing protein 11
DEG_APCC_DBOX_1
65:73
GRLELGDVE
APC,CDC20,FZR1
0.5555
More...