DegronMD

Uniprot ID: Q7Z572

Source protein: Spermatogenesis-associated protein 21

Source gene: SPATA21

Class: DEG_APCC_DBOX_1

Location: 355:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9085

ASA_SCORE: 102.2222

COIL: 0.732

CONS_SCORE: 0.4475

DSS_SCORE: 0.4358

HELIX: 0.205

FCONS_SCORE: 0.9956

RIG_SCORE: 0.7783

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R356W	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	0.8634
p.L360R	DO32928	PACA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.8428
p.S361R	DO229026	LICA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.7427
p.R356Q	ACH-001628	Ovarian Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	0.7329
p.Q360K	SIDM01060	Melanoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.5833
p.Q360K	SIDM01193	Glioma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.5833
p.Q360K	SIDM01170	Ovarian Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.5833
p.Q360K	SIDM00991	T-Lymphoblastic Leukemia	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.5833
p.V354I	TCGA-D7-A6EZ	STAD	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.3056
p.R354Q	DO219503	SKCM	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.3056
p.A353V	TCGA-AJ-A3EK	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.2778
p.A353D	TCGA-DX-A6YV	SARC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.2778
p.A353D	SIDM00697	Small Cell Lung Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.2778
p.A353D	ACH-000830	Lung Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	0.2778
p.A353D	NCI-H1436	lung	COSMIC	GRLRLQKLP	DEG_APCC_DBOX_1	0.2778
p.A352V	TCGA-A5-A0G1	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.25
p.A352V	TCGA-B5-A11E	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.25
p.A352V	TCGA-D1-A17Q	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.25
p.P366S	SIDM00554	Ovarian Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	0.25
p.P366S	KURAMOCHI	ovary	COSMIC	GRLRLQKLP	DEG_APCC_DBOX_1	0.25
p.E351K	TCGA-ER-A194	SKCM	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.2222
p.S349P	DO225048	BRCA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.1667
p.S348N	DO469	BLCA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.1389
p.S371N	TCGA-CF-A1HR	BLCA	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	0.1111
p.N371K	DO46420	OV	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	0.1111

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Drug responses associated with SPATA21 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GRLRLQKLP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z572	Spermatogenesis-associated protein 21	DEG_APCC_DBOX_1	355:363	GRLRLQKLP	APC,CDC20,FZR1	0.9085	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRLRLQKLP

Degron related mutations and impact score

Drug responses associated with SPATA21 mutations

All proteins holding degron of GRLRLQKLP