DegronMD - Q7Z572(SPATA21)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A352V	TCGA-A5-A0G1	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.A352V	TCGA-B5-A11E	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.A352V	TCGA-D1-A17Q	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.P114S	TCGA-A5-A0G2	UCEC	TCGA	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.25
p.S113L	TCGA-AB-2867	LAML	TCGA	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.2222
p.A353V	TCGA-AJ-A3EK	UCEC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.S371N	TCGA-CF-A1HR	BLCA	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.V354I	TCGA-D7-A6EZ	STAD	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.A353D	TCGA-DX-A6YV	SARC	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.A353D	SIDM00697	Small Cell Lung Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.A353D	ACH-000830	Lung Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.A353D	NCI-H1436	lung	COSMIC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.Q111H	TCGA-E2-A1IN	BRCA	TCGA	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1667
p.K112N	TCGA-EO-A3B0	UCEC	TCGA	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation substituting flanking lysine	0.3056
p.E351K	TCGA-ER-A194	SKCM	TCGA	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2222
p.S348N	DO469	BLCA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.S349P	DO225048	BRCA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.S110L	DO234387	ESAD	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1389
p.S110L	DO222775	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1389
p.S110L	DO47665	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1389
p.A111S	DO233069	GACA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1667
p.D114N	DO16136	KIRC	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.25
p.M131I	DO20872	KIRP	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.0833
p.S361R	DO229026	LICA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.7427
p.Q113K	DO229037	LICA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.2222
p.R120W	DO26674	LUSC	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation altering degron motif	0.8634
p.P126S	DO220886	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.2222
p.G132E	DO222599	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.0556
p.G132E	DO50284	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.0556
p.N371K	DO46420	OV	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.L360R	DO32928	PACA	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.8428
p.V128A	DO232445	PBCA	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.1667
p.G132R	DO37412	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.0556
p.G132R	DO50284	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation rewiring degron network	0.0556
p.W118L	DO37442	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation altering degron motif	0.7015
p.R354Q	DO219503	SKCM	ICGC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.G119R	DO38779	STAD	ICGC	LTPVPT	DEG_SCF_FBW7_1	117:122	Mutation altering degron motif	0.7568
p.Q360K	SIDM01060	Melanoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5833
p.Q360K	SIDM01193	Glioma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5833
p.Q360K	SIDM01170	Ovarian Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5833
p.Q360K	SIDM00991	T-Lymphoblastic Leukemia	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5833
p.P366S	SIDM00554	Ovarian Carcinoma	GDSC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.P366S	KURAMOCHI	ovary	COSMIC	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.R356W	ACH-000961	Endometrial/Uterine Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.8634
p.R356Q	ACH-001628	Ovarian Cancer	CCLE	GRLRLQKLP	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA21

UniProt ID: Q7Z572

Entrez ID: 374955

Protein name: Spermatogenesis-associated protein 21

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SPATA21 in