DegronMD

Uniprot ID: Q7Z572

Source protein: Spermatogenesis-associated protein 21

Source gene: SPATA21

Class: DEG_SCF_FBW7_1

Location: 117:122

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 85.0167

COIL: 0.943

CONS_SCORE: 0.4508

DSS_SCORE: 0.7332

HELIX: 0.0123

FCONS_SCORE: 1.1449

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P114S	TCGA-A5-A0G2	UCEC	TCGA	LTPVPT	DEG_SCF_FBW7_1	0.25
p.S113L	TCGA-AB-2867	LAML	TCGA	LTPVPT	DEG_SCF_FBW7_1	0.2222
p.Q111H	TCGA-E2-A1IN	BRCA	TCGA	LTPVPT	DEG_SCF_FBW7_1	0.1667
p.K112N	TCGA-EO-A3B0	UCEC	TCGA	LTPVPT	DEG_SCF_FBW7_1	0.3056
p.S110L	DO234387	ESAD	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.1389
p.S110L	DO222775	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.1389
p.S110L	DO47665	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.1389
p.A111S	DO233069	GACA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.1667
p.D114N	DO16136	KIRC	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.25
p.M131I	DO20872	KIRP	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.0833
p.Q113K	DO229037	LICA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.2222
p.R120W	DO26674	LUSC	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.8634
p.P126S	DO220886	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.2222
p.G132E	DO222599	MELA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.0556
p.G132E	DO50284	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.0556
p.V128A	DO232445	PBCA	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.1667
p.G132R	DO37412	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.0556
p.G132R	DO50284	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.0556
p.W118L	DO37442	SKCM	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.7015
p.G119R	DO38779	STAD	ICGC	LTPVPT	DEG_SCF_FBW7_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z572	Spermatogenesis-associated protein 21	DEG_SCF_FBW7_1	117:122	LTPVPT	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons