DegronMD

Uniprot ID: Q8N5W9

Source protein: Refilin-B

Source gene: RFLNB

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8645

ASA_SCORE: 66.8333

COIL: 0.6388

CONS_SCORE: 0.7723

DSS_SCORE: 0.6401

HELIX: 0.1866

FCONS_SCORE: 1.147

RIG_SCORE: 0.7704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1N	SIDM00935	Other Solid Cancers	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.3889
p.S1N	SIDM01110	Hepatocellular Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.3889
p.S1N	SIDM00853	Other Sarcomas	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.3889
p.A3P	SIDM00907	Burkitt's Lymphoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.7503
p.A3P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.7503
p.A3P	SIDM00760	Small Cell Lung Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.7503
p.A12V	SIDM00217	Colorectal Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	0.3056
p.A12V	SNU-1040	large_intestine	COSMIC	GRLSLQDVP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5W9	Refilin-B	DEG_APCC_DBOX_1	3:11	GRLSLQDVP	APC,CDC20,FZR1	0.8645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons