DegronMD - Q8N5W9(RFLNB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1N	SIDM00935	Other Solid Cancers	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation substituting flanking lysine	0.3889
p.S1N	SIDM01110	Hepatocellular Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation substituting flanking lysine	0.3889
p.S1N	SIDM00853	Other Sarcomas	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation substituting flanking lysine	0.3889
p.P28S	SIDM00969	Ovarian Carcinoma	GDSC	DSGLPPS	DEG_SCF_TRCP1_1	28:34	Mutation altering degron motif	0.6752
p.A3P	SIDM00907	Burkitt's Lymphoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7503
p.A3P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7503
p.A3P	SIDM00760	Small Cell Lung Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7503
p.A12V	SIDM00217	Colorectal Carcinoma	GDSC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.A12V	SNU-1040	large intestine	COSMIC	GRLSLQDVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons