DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGLPPS
Uniprot ID:
Q8N5W9
Source protein:
Refilin-B
Source gene:
RFLNB
Class:
DEG_SCF_TRCP1_1
Location:
28:34
E3 ligase:
BTRC
DEGRON score:
0.9986
ASA_SCORE:
58.1857
COIL:
0.9433
CONS_SCORE:
0.9906
DSS_SCORE:
0.7227
HELIX:
0.0354
FCONS_SCORE:
1.4844
RIG_SCORE:
0.5374
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P28S
SIDM00969
Ovarian Carcinoma
GDSC
DSGLPPS
DEG_SCF_TRCP1_1
0.6752
Drug responses associated with RFLNB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLPPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZTI6
Refilin-A
DEG_SCF_TRCP1_1
27:33
DSGLPPS
BTRC
0.9638
More...
Q8N5W9
Refilin-B
DEG_SCF_TRCP1_1
28:34
DSGLPPS
BTRC
0.9986
More...