DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGLPPS
Uniprot ID:
Q6ZTI6
Source protein:
Refilin-A
Source gene:
RFLNA
Class:
DEG_SCF_TRCP1_1
Location:
27:33
E3 ligase:
BTRC
DEGRON score:
0.9638
ASA_SCORE:
66.4
COIL:
0.956
CONS_SCORE:
0.6888
DSS_SCORE:
0.7709
HELIX:
0.025
FCONS_SCORE:
0.9209
RIG_SCORE:
0.5174
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RFLNA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLPPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZTI6
Refilin-A
DEG_SCF_TRCP1_1
27:33
DSGLPPS
BTRC
0.9638
More...
Q8N5W9
Refilin-B
DEG_SCF_TRCP1_1
28:34
DSGLPPS
BTRC
0.9986
More...