DegronMD

Uniprot ID: P35408

Source protein: Prostaglandin E2 receptor EP4 subtype

Source gene: PTGER4

Class: DEG_APCC_DBOX_1

Location: 411:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 78.2556

COIL: 0.854

CONS_SCORE: 0.2786

DSS_SCORE: 0.5396

HELIX: 0.0607

FCONS_SCORE: 0.9074

RIG_SCORE: 0.6785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G408S	TCGA-04-1342	OV	TCGA	GRNLLPGVP	DEG_APCC_DBOX_1	0.25
p.G408S	DO29548	OV	ICGC	GRNLLPGVP	DEG_APCC_DBOX_1	0.25
p.G408D	TCGA-B5-A3FC	UCEC	TCGA	GRNLLPGVP	DEG_APCC_DBOX_1	0.25
p.G408D	DO41871	UCEC	ICGC	GRNLLPGVP	DEG_APCC_DBOX_1	0.25
p.N413H	TCGA-BR-7196	STAD	TCGA	GRNLLPGVP	DEG_APCC_DBOX_1	0.6312
p.N413H	DO38235	STAD	ICGC	GRNLLPGVP	DEG_APCC_DBOX_1	0.6312
p.L401V	TCGA-HU-8238	STAD	TCGA	GRNLLPGVP	DEG_APCC_DBOX_1	0.0556
p.L401V	DO47944	STAD	ICGC	GRNLLPGVP	DEG_APCC_DBOX_1	0.0556
p.A424T	DO233697	GACA	ICGC	GRNLLPGVP	DEG_APCC_DBOX_1	0.1944
p.T428P	SIDM01525	Acute Myeloid Leukemia	GDSC	GRNLLPGVP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35408	Prostaglandin E2 receptor EP4 subtype	DEG_APCC_DBOX_1	411:419	GRNLLPGVP	APC,CDC20,FZR1	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons