DegronMD

Uniprot ID: P0CG20

Source protein: Proline-rich protein 35

Source gene: PRR35

Class: DEG_APCC_DBOX_1

Location: 485:493

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9895

ASA_SCORE: 65.2111

COIL: 0.8282

CONS_SCORE: 0.3261

DSS_SCORE: 0.6377

HELIX: 0.0344

FCONS_SCORE: 0.8706

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A483V	SIDM02050	Colorectal Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.2778
p.L489V	SIDM00338	Acute Myeloid Leukemia	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00373	Endometrial Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00260	Gastric Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00970	Bladder Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00397	Acute Myeloid Leukemia	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM00248	Gastric Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.L489V	SIDM01448	Head and Neck Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6765
p.P491L	SIDM01261	Breast Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6471
p.P491L	SIDM00314	Breast Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CG20	Proline-rich protein 35	DEG_APCC_DBOX_1	485:493	GRPELGPVL	APC,CDC20,FZR1	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons