DegronMD - P0CG20(PRR35)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A483V	SIDM02050	Colorectal Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation rewiring degron network	0.2778
p.L489V	SIDM00338	Acute Myeloid Leukemia	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00373	Endometrial Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00260	Gastric Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00970	Bladder Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00397	Acute Myeloid Leukemia	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM00248	Gastric Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.L489V	SIDM01448	Head and Neck Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6765
p.W371S	SIDM00072	Non-Cancerous	GDSC	PETPGPE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0833
p.P491L	SIDM01261	Breast Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6471
p.P491L	SIDM00314	Breast Carcinoma	GDSC	GRPELGPVL	DEG_APCC_DBOX_1	485:493	Mutation altering degron motif	0.6471
p.P396S	SIDM00304	Ovarian Carcinoma	GDSC	PETPGPE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0556
p.P396S	SIDM01473	Plasma Cell Myeloma	GDSC	PETPGPE	DEG_SCF_FBW7_2	380:386	Mutation rewiring degron network	0.0556

Kaplan plot for PRR35 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR35

UniProt ID: P0CG20

Entrez ID: 146325

Protein name: Proline-rich protein 35 (Uncharacterized protein RJD1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRR35 in