DegronMD

Uniprot ID: P0CG20

Source protein: Proline-rich protein 35

Source gene: PRR35

Class: DEG_SCF_FBW7_2

Location: 380:386

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 86.1286

COIL: 0.954

CONS_SCORE: 0.5214

DSS_SCORE: 0.8852

HELIX: 0.0163

FCONS_SCORE: 1.2219

RIG_SCORE: 0.4972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W371S	SIDM00072	Non-Cancerous	GDSC	PETPGPE	DEG_SCF_FBW7_2	0.0833
p.P396S	SIDM00304	Ovarian Carcinoma	GDSC	PETPGPE	DEG_SCF_FBW7_2	0.0556
p.P396S	SIDM01473	Plasma Cell Myeloma	GDSC	PETPGPE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CG20	Proline-rich protein 35	DEG_SCF_FBW7_2	380:386	PETPGPE	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons