DegronMD

Uniprot ID: P39059

Source protein: Collagen alpha-1

Source gene: COL15A1

Class: DEG_APCC_DBOX_1

Location: 912:920

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 81.2111

COIL: 0.96

CONS_SCORE: 0.5181

DSS_SCORE: 0.7724

HELIX: 0.0136

FCONS_SCORE: 1.1105

RIG_SCORE: 0.5776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P926T	TCGA-19-5951	GBM	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.1667
p.P926T	DO14067	GBM	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.1667
p.K920Q	TCGA-23-1117	OV	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.5833
p.K920Q	DO30830	OV	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.5833
p.G903R	TCGA-55-1595	LUAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.G903R	DO23558	LUAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.K920N	TCGA-77-A5GH	LUSC	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.5806
p.K920N	DO45452	LUSC	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.5806
p.G909W	TCGA-99-7458	LUAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.25
p.G909W	DO25416	LUAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.25
p.R913H	TCGA-BR-8382	STAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.8244
p.R913H	DO47925	STAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.8244
p.G903E	TCGA-EE-A2MS	SKCM	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.G903E	DO37567	SKCM	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.I929V	DO227549	COCA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.E904D	DO233731	GACA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.1111
p.L919I	DO229245	THCA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	0.6063
p.T922A	SIDM00845	Burkitt's Lymphoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	0.2778
p.P926R	SIDM00845	Burkitt's Lymphoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	0.1667
p.G909R	SIDM00596	Endometrial Carcinoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	0.25
p.G909R	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRPGLNGLK	DEG_APCC_DBOX_1	0.25
p.G909R	HEC-1	endometrium	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	0.25
p.P929R	NCI-H358	lung	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	0.0833
p.L922F	SN12C	kidney	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	0.2778
p.P928H	NCI-H747	large_intestine	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P39059	Collagen alpha-1	DEG_APCC_DBOX_1	912:920	GRPGLNGLK	APC,CDC20,FZR1	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRPGLNGLK

Degron related mutations and impact score

Drug responses associated with COL15A1 mutations

All proteins holding degron of GRPGLNGLK