DegronMD - P39059(COL15A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P926T	TCGA-19-5951	GBM	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.P926T	DO14067	GBM	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.K920Q	TCGA-23-1117	OV	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.5833
p.K920Q	DO30830	OV	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.5833
p.G903R	TCGA-55-1595	LUAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.G903R	DO23558	LUAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.G1034E	TCGA-55-8620	LUAD	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1389
p.G1034E	DO24547	LUAD	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1389
p.K920N	TCGA-77-A5GH	LUSC	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.5806
p.K920N	DO45452	LUSC	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.5806
p.G909W	TCGA-99-7458	LUAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.G909W	DO25416	LUAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.F1035V	TCGA-A5-A2K5	UCEC	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1111
p.F1035V	DO41379	UCEC	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1111
p.R913H	TCGA-BR-8382	STAD	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.8244
p.R913H	DO47925	STAD	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.8244
p.G903E	TCGA-EE-A2MS	SKCM	TCGA	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.G903E	DO37567	SKCM	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.D1015N	TCGA-FS-A1YY	SKCM	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.2222
p.D1015N	DO37415	SKCM	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.2222
p.I929V	DO227549	COCA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.E904D	DO233731	GACA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111
p.G1028W	DO229035	LICA	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.3056
p.L919I	DO229245	THCA	ICGC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation altering degron motif	0.6063
p.D1032N	SIDM00216	Colorectal Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1944
p.D1032N	ACH-000989	Colon/Colorectal Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1944
p.D1032N	SNU-175	large intestine	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1944
p.T922A	SIDM00845	Burkitt's Lymphoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.2778
p.P926R	SIDM00845	Burkitt's Lymphoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1667
p.G909R	SIDM00596	Endometrial Carcinoma	GDSC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.G909R	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.G909R	HEC-1	endometrium	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.25
p.P1010S	SIDM01045	Endometrial Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.0833
p.P1010S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.0833
p.P1010S	EN	endometrium	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.0833
p.L1019R	SIDM00587	Biliary Tract Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	SIDM00365	Small Cell Lung Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	SIDM01659	Kidney Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	ACH-000313	Kidney Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	ACH-000976	Bile Duct Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	ACH-001451	Cervical Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	ACH-002048	Sarcoma	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.L1019R	ACH-002196	Lung Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.7316
p.N1025K	SIDM00503	Gastric Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.5806
p.N1025K	ACH-000633	Gastric Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.5806
p.N1025K	FU97	stomach	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation altering degron motif	0.5806
p.N1011K	FU97	stomach	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.1111
p.P929R	NCI-H358	lung	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.0833
p.D1018N	SNU-175	large intestine	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	1019:1027	Mutation rewiring degron network	0.3056
p.L922F	SN12C	kidney	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.2778
p.P928H	NCI-H747	large intestine	COSMIC	GRPGLNGLK	DEG_APCC_DBOX_1	912:920	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL15A1

UniProt ID: P39059

Entrez ID: 1306

Protein name: Collagen alpha-1(XV) chain [Cleaved into: Restin (Endostatin-XV) (Related to endostatin) (Restin-I); Restin-2 (Restin-II); Restin-3 (Restin-III); Restin-4 (Restin-IV)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL15A1 in