DegronMD

Uniprot ID: P39059

Source protein: Collagen alpha-1

Source gene: COL15A1

Class: DEG_APCC_DBOX_1

Location: 1019:1027

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6353

ASA_SCORE: 84.9778

COIL: 0.7993

CONS_SCORE: 0.382

DSS_SCORE: 0.4838

HELIX: 0.1534

FCONS_SCORE: 0.8552

RIG_SCORE: 0.7961

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1034E	TCGA-55-8620	LUAD	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	0.1389
p.G1034E	DO24547	LUAD	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	0.1389
p.F1035V	TCGA-A5-A2K5	UCEC	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	0.1111
p.F1035V	DO41379	UCEC	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	0.1111
p.D1015N	TCGA-FS-A1YY	SKCM	TCGA	LRHFLNNLK	DEG_APCC_DBOX_1	0.2222
p.D1015N	DO37415	SKCM	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	0.2222
p.G1028W	DO229035	LICA	ICGC	LRHFLNNLK	DEG_APCC_DBOX_1	0.3056
p.D1032N	SIDM00216	Colorectal Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.1944
p.D1032N	ACH-000989	Colon/Colorectal Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.1944
p.D1032N	SNU-175	large_intestine	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	0.1944
p.P1010S	SIDM01045	Endometrial Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.0833
p.P1010S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.0833
p.P1010S	EN	endometrium	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	0.0833
p.L1019R	SIDM00587	Biliary Tract Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	SIDM00365	Small Cell Lung Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	SIDM01659	Kidney Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	ACH-000313	Kidney Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	ACH-000976	Bile Duct Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	ACH-001451	Cervical Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	ACH-002048	Sarcoma	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.L1019R	ACH-002196	Lung Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.7316
p.N1025K	SIDM00503	Gastric Carcinoma	GDSC	LRHFLNNLK	DEG_APCC_DBOX_1	0.5806
p.N1025K	ACH-000633	Gastric Cancer	CCLE	LRHFLNNLK	DEG_APCC_DBOX_1	0.5806
p.N1025K	FU97	stomach	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	0.5806
p.N1011K	FU97	stomach	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	0.1111
p.D1018N	SNU-175	large_intestine	COSMIC	LRHFLNNLK	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRHFLNNLK

Degron related mutations and impact score

Drug responses associated with COL15A1 mutations

All proteins holding degron of LRHFLNNLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P39059	Collagen alpha-1	DEG_APCC_DBOX_1	1019:1027	LRHFLNNLK	APC,CDC20,FZR1	0.6353	More...