DegronMD

Uniprot ID: Q9BYK8

Source protein: Helicase with zinc finger domain 2

Source gene: HELZ2

Class: DEG_APCC_DBOX_1

Location: 1787:1795

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6032

ASA_SCORE: 55.1667

COIL: 0.4007

CONS_SCORE: 0.4722

DSS_SCORE: 0.29

HELIX: 0.0069

FCONS_SCORE: 0.9179

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1796G	DO218998	BLCA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.3056
p.A1779V	DO9708	COAD	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1111
p.V1785M	DO230311	COCA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.2778
p.A1793V	DO233621	GACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.6936
p.L1780R	DO233736	GACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1389
p.L1783M	DO228948	LICA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.2222
p.M1795V	DO45201	LIRI	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.7208
p.M1795V	DO219778	UCEC	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.7208
p.T1797M	DO51537	PACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.2778
p.L1783P	DO47819	STAD	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	0.2222
p.A1802V	SIDM00586	Hepatocellular Carcinoma	GDSC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1389
p.A1802V	SIDM00589	Oral Cavity Carcinoma	GDSC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1389
p.H1783Y	ACH-000117	Breast Cancer	CCLE	GRPGLRLLW	DEG_APCC_DBOX_1	0.2222
p.R1796Q	ACH-002069	Bone Cancer	CCLE	GRPGLRLLW	DEG_APCC_DBOX_1	0.3056
p.A1793T	CL-40	large_intestine	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	0.7139
p.L1802V	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1389
p.L1802V	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYK8	Helicase with zinc finger domain 2	DEG_APCC_DBOX_1	1787:1795	GRPGLRLLW	APC,CDC20,FZR1	0.6032	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons