DegronMD - Q9BYK8(HELZ2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1150T	TCGA-33-4566	LUSC	TCGA	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.1944
p.R2243H	TCGA-B5-A11E	UCEC	TCGA	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation altering degron motif	0.7133
p.R2235G	TCGA-B9-4113	KIRP	TCGA	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.1389
p.R2236M	TCGA-EO-A22R	UCEC	TCGA	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.1667
p.G1153D	TCGA-QH-A870	LGG	TCGA	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.2778
p.A1796G	DO218998	BLCA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.3056
p.A1779V	DO9708	COAD	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1111
p.V1785M	DO230311	COCA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.2778
p.R1153Q	DO234258	ESAD	ICGC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.2778
p.R1156H	DO234317	ESAD	ICGC	IQVRGR	SCF_FBXL2	1155:1160	Mutation altering degron motif	0.8244
p.A1793V	DO233621	GACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation altering degron motif	0.6936
p.L1780R	DO233736	GACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1389
p.L1783M	DO228948	LICA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.2222
p.A1166D	DO229038	LICA	ICGC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.1667
p.H1159Q	DO229009	LICA	ICGC	IQVRGR	SCF_FBXL2	1155:1160	Mutation altering degron motif	0.7582
p.M1795V	DO45201	LIRI	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation altering degron motif	0.7208
p.M1795V	DO219778	UCEC	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation altering degron motif	0.7208
p.T1797M	DO51537	PACA	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.2778
p.L1783P	DO47819	STAD	ICGC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.2222
p.A1146T	DO42472	UCEC	ICGC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.0833
p.A1802V	SIDM00586	Hepatocellular Carcinoma	GDSC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1389
p.A1802V	SIDM00589	Oral Cavity Carcinoma	GDSC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1389
p.V2256M	SIDM00393	Gastric Carcinoma	GDSC	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.0833
p.V2256M	ACH-001653	Gastric Cancer	CCLE	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.0833
p.V2256M	SK-GT-2	stomach	COSMIC	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.0833
p.S1152L	SIDM00694	Other Solid Cancers	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM00849	Kidney Carcinoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM00254	Neuroblastoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM00954	Breast Carcinoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM00863	Burkitt's Lymphoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM01608	Endometrial Carcinoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.S1152L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.25
p.M2237V	SIDM01728	Endometrial Carcinoma	GDSC	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.1944
p.M2237V	ACH-000173	Endometrial/Uterine Cancer	CCLE	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.1944
p.H1783Y	ACH-000117	Breast Cancer	CCLE	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.2222
p.R2235K	ACH-000338	Lymphoma	CCLE	LRVYSE	LIG_APCC_ABBA_1	2242:2247	Mutation rewiring degron network	0.1389
p.G1169E	ACH-000989	Colon/Colorectal Cancer	CCLE	IQVRGR	SCF_FBXL2	1155:1160	Mutation rewiring degron network	0.0833
p.R1796Q	ACH-002069	Bone Cancer	CCLE	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.3056
p.A1793T	CL-40	large intestine	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation altering degron motif	0.7139
p.L1802V	U-266	haematopoietic and lymphoid tissue	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1389
p.L1802V	MEG-01	haematopoietic and lymphoid tissue	COSMIC	GRPGLRLLW	DEG_APCC_DBOX_1	1787:1795	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HELZ2

UniProt ID: Q9BYK8

Entrez ID: 85441

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HELZ2 in