DegronMD

Uniprot ID: Q9BYK8

Source protein: Helicase with zinc finger domain 2

Source gene: HELZ2

Class: SCF_FBXL2

Location: 1155:1160

E3 ligase: FBXL2

DEGRON score: 0.5978

ASA_SCORE: 56.3833

COIL: 0.481

CONS_SCORE: 0.6197

DSS_SCORE: 0.3435

HELIX: 0.068

FCONS_SCORE: 1.1824

RIG_SCORE: 0.7812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1150T	TCGA-33-4566	LUSC	TCGA	IQVRGR	SCF_FBXL2	0.1944
p.G1153D	TCGA-QH-A870	LGG	TCGA	IQVRGR	SCF_FBXL2	0.2778
p.R1153Q	DO234258	ESAD	ICGC	IQVRGR	SCF_FBXL2	0.2778
p.R1156H	DO234317	ESAD	ICGC	IQVRGR	SCF_FBXL2	0.8244
p.A1166D	DO229038	LICA	ICGC	IQVRGR	SCF_FBXL2	0.1667
p.H1159Q	DO229009	LICA	ICGC	IQVRGR	SCF_FBXL2	0.7582
p.A1146T	DO42472	UCEC	ICGC	IQVRGR	SCF_FBXL2	0.0833
p.S1152L	SIDM00694	Other Solid Cancers	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM00849	Kidney Carcinoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM00254	Neuroblastoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM00954	Breast Carcinoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM00863	Burkitt's Lymphoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM01608	Endometrial Carcinoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.S1152L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IQVRGR	SCF_FBXL2	0.25
p.G1169E	ACH-000989	Colon/Colorectal Cancer	CCLE	IQVRGR	SCF_FBXL2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYK8	Helicase with zinc finger domain 2	SCF_FBXL2	1155:1160	IQVRGR	FBXL2	0.5978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons