DegronMD

Uniprot ID: Q9BYK8

Source protein: Helicase with zinc finger domain 2

Source gene: HELZ2

Class: LIG_APCC_ABBA_1

Location: 2242:2247

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5068

ASA_SCORE: 64.65

COIL: 0.399

CONS_SCORE: 0.7659

DSS_SCORE: 0.2404

HELIX: 0.258

FCONS_SCORE: 1.3196

RIG_SCORE: 0.7897

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2243H	TCGA-B5-A11E	UCEC	TCGA	LRVYSE	LIG_APCC_ABBA_1	0.7133
p.M2237V	SIDM01728	Endometrial Carcinoma	GDSC	LRVYSE	LIG_APCC_ABBA_1	0.1944
p.M2237V	ACH-000173	Endometrial/Uterine Cancer	CCLE	LRVYSE	LIG_APCC_ABBA_1	0.1944
p.R2236M	TCGA-EO-A22R	UCEC	TCGA	LRVYSE	LIG_APCC_ABBA_1	0.1667
p.R2235G	TCGA-B9-4113	KIRP	TCGA	LRVYSE	LIG_APCC_ABBA_1	0.1389
p.R2235K	ACH-000338	Lymphoma	CCLE	LRVYSE	LIG_APCC_ABBA_1	0.1389
p.V2256M	SIDM00393	Gastric Carcinoma	GDSC	LRVYSE	LIG_APCC_ABBA_1	0.0833
p.V2256M	ACH-001653	Gastric Cancer	CCLE	LRVYSE	LIG_APCC_ABBA_1	0.0833
p.V2256M	SK-GT-2	stomach	COSMIC	LRVYSE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYK8	Helicase with zinc finger domain 2	LIG_APCC_ABBA_1	2242:2247	LRVYSE	APC,CDC20,FZR1	0.5068	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons