DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRVYSE
Uniprot ID:
Q9BYK8
Source protein:
Helicase with zinc finger domain 2
Source gene:
HELZ2
Class:
LIG_APCC_ABBA_1
Location:
2242:2247
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5068
ASA_SCORE:
64.65
COIL:
0.399
CONS_SCORE:
0.7659
DSS_SCORE:
0.2404
HELIX:
0.258
FCONS_SCORE:
1.3196
RIG_SCORE:
0.7897
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R2243H
TCGA-B5-A11E
UCEC
TCGA
LRVYSE
LIG_APCC_ABBA_1
0.7133
p.R2235G
TCGA-B9-4113
KIRP
TCGA
LRVYSE
LIG_APCC_ABBA_1
0.1389
p.R2236M
TCGA-EO-A22R
UCEC
TCGA
LRVYSE
LIG_APCC_ABBA_1
0.1667
p.V2256M
SIDM00393
Gastric Carcinoma
GDSC
LRVYSE
LIG_APCC_ABBA_1
0.0833
p.V2256M
ACH-001653
Gastric Cancer
CCLE
LRVYSE
LIG_APCC_ABBA_1
0.0833
p.V2256M
SK-GT-2
stomach
COSMIC
LRVYSE
LIG_APCC_ABBA_1
0.0833
p.M2237V
SIDM01728
Endometrial Carcinoma
GDSC
LRVYSE
LIG_APCC_ABBA_1
0.1944
p.M2237V
ACH-000173
Endometrial/Uterine Cancer
CCLE
LRVYSE
LIG_APCC_ABBA_1
0.1944
p.R2235K
ACH-000338
Lymphoma
CCLE
LRVYSE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with HELZ2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRVYSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYK8
Helicase with zinc finger domain 2
LIG_APCC_ABBA_1
2242:2247
LRVYSE
APC,CDC20,FZR1
0.5068
More...