DegronMD

Uniprot ID: Q9H201

Source protein: Epsin-3

Source gene: EPN3

Class: DEG_APCC_DBOX_1

Location: 545:553

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9936

ASA_SCORE: 78.7222

COIL: 0.6589

CONS_SCORE: 0.348

DSS_SCORE: 0.6802

HELIX: 0.3148

FCONS_SCORE: 1.2365

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P535H	TCGA-EB-A299	SKCM	TCGA	GRPTLNQMR	DEG_APCC_DBOX_1	0.0556
p.P535H	DO37794	SKCM	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.0556
p.A541V	DO222926	BTCA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.2222
p.P544T	DO229003	COCA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.3056
p.P544T	DO228941	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.3056
p.P544T	DO229047	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.3056
p.P544T	DO231075	LUSC	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.3056
p.P544T	DO231207	LUSC	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.3056
p.G545C	DO229034	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	0.6489
p.T536I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	0.0833
p.T536I	ACH-000843	Lung Cancer	CCLE	GRPTLNQMR	DEG_APCC_DBOX_1	0.0833
p.T536I	HARA	lung	COSMIC	GRPTLNQMR	DEG_APCC_DBOX_1	0.0833
p.T536N	SIDM00254	Neuroblastoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	0.0833
p.T536N	SIDM00721	Small Cell Lung Carcinoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H201	Epsin-3	DEG_APCC_DBOX_1	545:553	GRPTLNQMR	APC,CDC20,FZR1	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons