DegronMD - Q9H201(EPN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S463C	TCGA-58-8386	LUSC	TCGA	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.1944
p.S463C	DO45537	LUSC	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.1944
p.P443S	TCGA-AA-3864	COAD	TCGA	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.0556
p.P443S	DO8490	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.0556
p.G467V	TCGA-AP-A056	UCEC	TCGA	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.0833
p.G467V	DO43971	UCEC	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.0833
p.W361R	TCGA-AX-A0J0	UCEC	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.W361R	DO41133	UCEC	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.P459H	TCGA-AZ-6598	COAD	TCGA	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.3056
p.P459H	DO10276	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.3056
p.S370A	TCGA-BR-A4QL	STAD	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.S370A	DO38723	STAD	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.S462N	TCGA-CR-6478	HNSC	TCGA	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.2222
p.S462N	DO15839	HNSC	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.2222
p.P535H	TCGA-EB-A299	SKCM	TCGA	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.P535H	DO37794	SKCM	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0556
p.W361C	TCGA-EE-A183	SKCM	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.W361C	DO37715	SKCM	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.2778
p.V354I	TCGA-EX-A3L1	CESC	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	TCGA-VQ-A91D	STAD	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	DO6335	CESC	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	DO51783	STAD	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	ACH-002272	Lymphoma	CCLE	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.V354I	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.0833
p.R357Q	TCGA-EY-A1GI	UCEC	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.R357Q	DO41211	UCEC	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.T376N	TCGA-WE-A8ZN	SKCM	TCGA	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1111
p.T376N	DO51285	SKCM	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1111
p.A541V	DO222926	BTCA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.2222
p.F456L	DO8264	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation altering degron motif	0.6981
p.P544T	DO229003	COCA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.3056
p.P544T	DO228941	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.3056
p.P544T	DO229047	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.3056
p.P544T	DO231075	LUSC	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.3056
p.P544T	DO231207	LUSC	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.3056
p.P360L	DO228190	LICA	ICGC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.25
p.G545C	DO229034	LICA	ICGC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation altering degron motif	0.6489
p.K446N	DO229004	LICA	ICGC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation substituting flanking lysine	0.25
p.R357G	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.R357G	SIDM00529	Breast Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.R357G	SIDM00493	Other Solid Cancers	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.R357G	SIDM01525	Acute Myeloid Leukemia	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation rewiring degron network	0.1667
p.P450H	SIDM00789	Colorectal Carcinoma	GDSC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.P450H	ACH-000997	Colon/Colorectal Cancer	CCLE	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.P450H	HCT-15	large intestine	COSMIC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.T536I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.T536I	ACH-000843	Lung Cancer	CCLE	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.T536I	HARA	lung	COSMIC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.P461S	SIDM00529	Breast Carcinoma	GDSC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.P461S	SIDM00493	Other Solid Cancers	GDSC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.P461S	SIDM01525	Acute Myeloid Leukemia	GDSC	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation rewiring degron network	0.25
p.T536N	SIDM00254	Neuroblastoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.T536N	SIDM00721	Small Cell Lung Carcinoma	GDSC	GRPTLNQMR	DEG_APCC_DBOX_1	545:553	Mutation rewiring degron network	0.0833
p.L367F	SIDM01612	Endometrial Carcinoma	GDSC	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation altering degron motif	0.587
p.L367F	ACH-000946	Endometrial/Uterine Cancer	CCLE	LTPMLS	DEG_SCF_FBW7_1	363:368	Mutation altering degron motif	0.587
p.S444F	ACH-001407	Bladder Cancer	CCLE	LDLFGD	LIG_APCC_ABBA_1	453:458	Mutation blocking phosphorylation signal	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPN3

UniProt ID: Q9H201

Entrez ID: 55040

Protein name: Epsin-3 (EPS-15-interacting protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPN3 in