DegronMD

Uniprot ID: Q9H201

Source protein: Epsin-3

Source gene: EPN3

Class: LIG_APCC_ABBA_1

Location: 453:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 61.45

COIL: 0.8288

CONS_SCORE: 0.3306

DSS_SCORE: 0.7504

HELIX: 0.1045

FCONS_SCORE: 1.1996

RIG_SCORE: 0.6633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S463C	TCGA-58-8386	LUSC	TCGA	LDLFGD	LIG_APCC_ABBA_1	0.1944
p.S463C	DO45537	LUSC	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.1944
p.P443S	TCGA-AA-3864	COAD	TCGA	LDLFGD	LIG_APCC_ABBA_1	0.0556
p.P443S	DO8490	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.0556
p.G467V	TCGA-AP-A056	UCEC	TCGA	LDLFGD	LIG_APCC_ABBA_1	0.0833
p.G467V	DO43971	UCEC	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.0833
p.P459H	TCGA-AZ-6598	COAD	TCGA	LDLFGD	LIG_APCC_ABBA_1	0.3056
p.P459H	DO10276	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.3056
p.S462N	TCGA-CR-6478	HNSC	TCGA	LDLFGD	LIG_APCC_ABBA_1	0.2222
p.S462N	DO15839	HNSC	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.2222
p.F456L	DO8264	COAD	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.6981
p.K446N	DO229004	LICA	ICGC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P450H	SIDM00789	Colorectal Carcinoma	GDSC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P450H	ACH-000997	Colon/Colorectal Cancer	CCLE	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P450H	HCT-15	large_intestine	COSMIC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P461S	SIDM00529	Breast Carcinoma	GDSC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P461S	SIDM00493	Other Solid Cancers	GDSC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.P461S	SIDM01525	Acute Myeloid Leukemia	GDSC	LDLFGD	LIG_APCC_ABBA_1	0.25
p.S444F	ACH-001407	Bladder Cancer	CCLE	LDLFGD	LIG_APCC_ABBA_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H201	Epsin-3	LIG_APCC_ABBA_1	453:458	LDLFGD	APC,CDC20,FZR1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons